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Tbio
TECTB
Beta-tectorin

Protein Summary
Description
One of the major non-collagenous components of the tectorial membrane (By similarity). The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. This gene encodes a non-collagenous glycoprotein component of the tectorial membrane, which covers the auditory hair cells in the cochlea of the inner ear. A similar protein in mouse functions in low-frequency hearing. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369422
  • ENSP00000358430
  • ENSG00000119913
  • ENST00000646139
  • ENSP00000494896
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.59
gene perturbation
0.47
cell line
0.45
cell type or tissue
0.35
biological term
0.34


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.32   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.32   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (106)
OTOA
Tbio
Novelty:  0.04940755
Score:  0.979
Data Source:  STRINGDB
CEACAM7
Tbio
Novelty:  0.05266788
Score:  0.942
Data Source:  STRINGDB
TECTA
Tbio
Novelty:  0.02462336
Score:  0.935
Data Source:  STRINGDB
XPNPEP2
Tchem
Family:  Enzyme
Novelty:  0.01453123
Score:  0.918
Data Source:  STRINGDB
CEACAM5
Tbio
Novelty:  0.00007291
Score:  0.912
Data Source:  STRINGDB
ALPL
Tchem
Family:  Enzyme
Novelty:  0.00152281
Score:  0.906
Data Source:  STRINGDB
ALPI
Tchem
Family:  Enzyme
Novelty:  0.00559196
Score:  0.906
Data Source:  STRINGDB
NTNG1
Tbio
Novelty:  0.04742965
Score:  0.904
Data Source:  STRINGDB
THY1
Tbio
Novelty:  0.00032846
Score:  0.904
Data Source:  STRINGDB
ALPG
Tchem
Family:  Enzyme
Novelty:  0.00577814
Score:  0.903
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
6
97.1
high density lipoprotein cholesterol measurement
6
5
10
93.5
total cholesterol measurement
4
4
7
87.6
alkaline phosphatase measurement
3
2
2
12.3
87.4
low density lipoprotein cholesterol measurement
2
2
5
83.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
6
97.1
high density lipoprotein cholesterol measurement
10
93.5
total cholesterol measurement
7
87.6
alkaline phosphatase measurement
2
12.3
87.4
low density lipoprotein cholesterol measurement
5
83.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tectorin beta
VGNC:12508
466202
Macaque
tectorin beta
696153
Mouse
MGI:109574
21684
Rat
RGD:1305835
292124
Dog
tectorin beta
VGNC:47237
486891
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tectorin beta
Macaque
tectorin beta
Mouse
Rat
Dog
tectorin beta
Publication Statistics
PubMed Score 23.32
PubMed score by year
PubTator Score 3.23
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title