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Tbio
RBM14
RNA-binding protein 14

Protein Summary
Description
Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 (PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ (PubMed:25385835). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). This locus represents naturally occurring read-through transcri ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310137
  • ENSP00000311747
  • ENSG00000239306
  • ENST00000393979
  • ENSP00000377548
  • ENST00000409738
  • ENSP00000386995

Symbol
  • SIP
  • SIP
  • COAZ
  • PSP2
  • RBM14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein complex
0.95
transcription factor binding site profile
0.92
virus perturbation
0.92
transcription factor perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.02   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.02   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
2
2
65.7
apolipoprotein B measurement
2
2
2
65.7
insomnia measurement
1
2
0
1.1
57.1
BMI-adjusted hip circumference
1
1
1
35
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
65.7
apolipoprotein B measurement
2
65.7
insomnia measurement
0
1.1
57.1
BMI-adjusted hip circumference
1
35
1
29
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RNA binding motif protein 14
VGNC:1026
451349
Mouse
MGI:1929092
56275
Rat
RGD:620542
170900
Dog
RNA binding motif protein 14
VGNC:45408
610648
Cow
RNA binding motif protein 14
511512
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RNA binding motif protein 14
Mouse
Rat
Dog
RNA binding motif protein 14
Cow
RNA binding motif protein 14
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96PK6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
RUNX2 regulates bone development
Reactome
Transcriptional regulation by RUNX2
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
RUNX2 regulates bone development
Transcriptional regulation by RUNX2
Protein-Protein Interactions (229)
1 – 10 of 229
SURF2
Tdark
Novelty:  0.10662558
p_int:  0.999932307
p_ni:  0.000067644
p_wrong:  4.9e-8
Data Source:  BioPlex
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.999849567
p_ni:  0.000150433
Data Source:  BioPlex
TMEM206
Tdark
Novelty:  0.17311172
p_int:  0.999293724
p_ni:  0.000704844
p_wrong:  0.000001433
Data Source:  BioPlex
LOXL2
Tchem
Family:  Enzyme
Novelty:  0.00599536
p_int:  0.999274461
p_ni:  0.000725536
p_wrong:  3e-9
Data Source:  BioPlex
GADL1
Tbio
Family:  Enzyme
Novelty:  0.018813
p_int:  0.999168731
p_ni:  0.000830176
p_wrong:  0.000001093
Data Source:  BioPlex
SIRT6
Tchem
Family:  Epigenetic
Novelty:  0.00155366
p_int:  0.99901856
p_ni:  0.000981276
p_wrong:  1.65e-7
Data Source:  BioPlex
SERPINB13
Tbio
Novelty:  0.01753451
p_int:  0.998947061
p_ni:  0.001051393
p_wrong:  0.000001547
Data Source:  BioPlex
AP1G2
Tbio
Novelty:  0.17203425
p_int:  0.998943387
p_ni:  0.00105649
p_wrong:  1.23e-7
Data Source:  BioPlex
F9
Tchem
Family:  Enzyme
Novelty:  0.00032127
p_int:  0.99848729
p_ni:  0.001512315
p_wrong:  3.95e-7
Data Source:  BioPlex
CTBP1
Tbio
Novelty:  0.00243818
p_int:  0.997882778
p_ni:  0.001011782
p_wrong:  0.00110544
Data Source:  BioPlex
Publication Statistics
PubMed Score  80.02

PubMed score by year
PubTator Score  3.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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