Tbio DEFB118 Beta-defensin 118

Protein Summary

Description

Has antibacterial activity. This gene encodes a member of the beta subfamily of defensins. Beta-defensins are antimicrobial peptides that protect tissues and organs from infection by a variety of microorganisms. Expression of this gene is regulated by androgen, and the encoded protein binds to sperm and exhibits antibacterial activity against E. coli. This gene is found in a cluster with other beta-defensin genes on the long arm of chromosome 20. [provided by RefSeq, Nov 2014]

Uniprot Accession IDs

• Q96PH6
• Q17RC4
• Q8N691
• Q9NUH0

Gene Name

• DEFB118

Ensembl ID

• ENST00000253381
• ENSP00000253381
• ENSG00000131068

Symbol

• C20orf63
• DEFB18
• ESC42
• ESC42
• DEFB-18
• ESP13.6
• C20orf63

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue	0.48
phenotype	0.46
cell line	0.4
biological term	0.33
microRNA	0.33

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.39   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 12   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.39   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 12   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0