Tchem NOX5 NADPH oxidase 5

Protein Summary

Description

Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin. This gene is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes. It encodes a calcium-dependen NADPH oxidase that generates superoxide, and functions as a calcium-dependent proton channel that may regulate redox-dependent processes in lymphocytes and spermatozoa. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• Q96PH1
• B2RBJ4
• Q08AN2
• Q08AN3
• Q8TEQ1
• Q8TER4
• Q96PH2
• Q96PJ8
• Q96PJ9
• Q9H6E0
• Q9HAM8

Gene Name

• NOX5

Ensembl ID

• ENST00000260364
• ENSP00000454143
• ENSG00000255346
• ENST00000388866
• ENSP00000373518
• ENST00000448182
• ENSP00000410887
• ENST00000455873
• ENSP00000416828
• ENST00000530406
• ENSP00000432440

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
molecular function	0.97
cell type or tissue	0.78
tissue	0.73
kinase	0.58

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxidase / Nadph Oxidase 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.35   (req: < 5)

Gene RIFs: 61   (req: <= 3)

Antibodies: 223   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.35   (req: >= 5)

Gene RIFs: 61   (req: > 3)

Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 17

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (3)

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (17)

Explore Active Ligands

1 – 10 of 17

CHEMBL1927147

NOX5Tchem Enzyme

pKi : 6.38

GKT137831

NOX5Tchem Enzyme

pKi : 6.39

NSC 780521

NOX5Tchem Enzyme

pIC50 : 6.64

CHEMBL1927146

NOX5Tchem Enzyme

pKi : 6.44

CHEMBL1927160

NOX5Tchem Enzyme

pKi : 6.31

CHEMBL1927158

NOX5Tchem Enzyme

pKi : 6.21

CHEMBL1927148

NOX5Tchem Enzyme

pKi : 6.17

CHEMBL1927154

NOX5Tchem Enzyme

pKi : 6.16

CHEMBL1927159

NOX5Tchem Enzyme

pKi : 6.16

CHEMBL1927155

NOX5Tchem Enzyme

pKi : 6.02

Protein-Protein Interactions (42)

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1 – 10 of 42

• See Interactions on String-DB

MTHFR

Tbio

Family:  Enzyme

Novelty:  0.00018162

p_int:  0.999556456

p_ni:  0.000443544

Score:  0.202

Data Source:  BioPlex,STRINGDB

GUCY1B1

Tclin

Family:  Enzyme

Novelty:  0.03618378

p_int:  0.999502657

p_ni:  0.000497262

p_wrong:  8.2e-8

Score:  0.38

Data Source:  BioPlex,STRINGDB

PDP2

Tbio

Family:  Enzyme

Novelty:  0.0259516

p_int:  0.991203791

p_ni:  0.000555628

p_wrong:  0.008240581

Score:  0.245

Data Source:  BioPlex,STRINGDB

TTC4

Tbio

Novelty:  0.00808711

p_int:  0.975771114

p_ni:  0.024228886

Score:  0.243

Data Source:  BioPlex,STRINGDB

HSPA8

Tchem

Novelty:  0.00081014

p_int:  0.965457606

p_ni:  0.034542394

Score:  0.217

Data Source:  BioPlex,STRINGDB

PRKAR1B

Tbio

Family:  Enzyme

Novelty:  0.05355517

p_int:  0.944362699

p_ni:  0.055637301

Score:  0.186

Data Source:  BioPlex,STRINGDB

STIP1

Tbio

Novelty:  0.00590952

p_int:  0.937972169

p_ni:  0.062027831

Score:  0.158

Data Source:  BioPlex,STRINGDB

DDRGK1

Tbio

Novelty:  0.10774064

p_int:  0.866627675

p_ni:  0.133372325

Score:  0.175

Data Source:  BioPlex,STRINGDB

CYBA

Tbio

Novelty:  0.00177762

Score:  0.871

Data Source:  STRINGDB

NCF2

Tbio

Novelty:  0.00274685

Score:  0.853

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (10)

Reactome (3)

WikiPathways (7)

Cellular responses to external stimuli (R-HSA-8953897)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897
Reactome	Cellular responses to stress	392 targets	R-HSA-2262752
Reactome	Detoxification of Reactive Oxygen Species	37 targets	R-HSA-3299685

Name	Explore in Pharos	Explore in Source
Cellular responses to external stimuli	487 targets	R-HSA-8953897
Cellular responses to stress	392 targets	R-HSA-2262752
Detoxification of Reactive Oxygen Species	37 targets	R-HSA-3299685

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (21)

Functions (6)

Components (3)

Processes (12)

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1 – 6 of 6

GO Term	Evidence	Assigned by
proton channel activity	Inferred from Direct Assay (IDA)	UniProtKB
superoxide-generating NADPH oxidase activity	Inferred from Direct Assay (IDA)	UniProtKB
flavin adenine dinucleotide binding	Non-traceable Author Statement (NAS)	UniProtKB
heme binding	Non-traceable Author Statement (NAS)	UniProtKB
NADP binding	Non-traceable Author Statement (NAS)	UniProtKB
calcium ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (0)

No GWAS traits found

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UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Angiogenesis
Calcium
Complete proteome
Electron transport
Endoplasmic reticulum
FAD
Flavoprotein
Ion channel
Ion transport

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	NADPH oxidase 5		748494
Macaque	NADPH oxidase 5 [Source:HGNC Symbol;Acc:HGNC:14874]
Dog	NADPH oxidase 5	VGNC:43906	487620
Horse	NADPH oxidase 5		100034218
Cow	NADPH oxidase 5	VGNC:32185	531303

Species	Name	OMA	EggNOG	Inparanoid
Chimp	NADPH oxidase 5
Macaque	NADPH oxidase 5 [Source:HGNC Symbol;Acc:HGNC:14874]
Dog	NADPH oxidase 5
Horse	NADPH oxidase 5
Cow	NADPH oxidase 5

Publication Statistics

PubMed Score 159.35

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PubTator Score 97.63

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Related Publications

Text Mined References (71)

GeneRif Annotations (61)

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PMID	Year	Title