Protein Summary
Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin. This gene is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes. It encodes a calcium-dependen NADPH oxidase that generates superoxide, and functions as a calcium-dependent proton channel that may regulate redox-dependent processes in lymphocytes and spermatozoa. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
- ENST00000260364
- ENSP00000454143
- ENSG00000255346
- ENST00000388866
- ENSP00000373518
- ENST00000448182
- ENSP00000410887
- ENST00000455873
- ENSP00000416828
- ENST00000530406
- ENSP00000432440
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.99 | ||
molecular function | 0.97 | ||
cell type or tissue | 0.78 | ||
tissue | 0.73 | ||
kinase | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 159.35 (req: < 5)
Gene RIFs: 61 (req: <= 3)
Antibodies: 223 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 159.35 (req: >= 5)
Gene RIFs: 61 (req: > 3)
Antibodies: 223 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 17
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (17)
Protein-Protein Interactions (42)
MTHFR
Family: Enzyme
Novelty: 0.00018162
p_int: 0.999556456
p_ni: 0.000443544
Score: 0.202
Data Source: BioPlex,STRINGDB
GUCY1B1
Family: Enzyme
Novelty: 0.03618378
p_int: 0.999502657
p_ni: 0.000497262
p_wrong: 8.2e-8
Score: 0.38
Data Source: BioPlex,STRINGDB
PDP2
Family: Enzyme
Novelty: 0.0259516
p_int: 0.991203791
p_ni: 0.000555628
p_wrong: 0.008240581
Score: 0.245
Data Source: BioPlex,STRINGDB
TTC4
Novelty: 0.00808711
p_int: 0.975771114
p_ni: 0.024228886
Score: 0.243
Data Source: BioPlex,STRINGDB
HSPA8
Novelty: 0.00081014
p_int: 0.965457606
p_ni: 0.034542394
Score: 0.217
Data Source: BioPlex,STRINGDB
PRKAR1B
Family: Enzyme
Novelty: 0.05355517
p_int: 0.944362699
p_ni: 0.055637301
Score: 0.186
Data Source: BioPlex,STRINGDB
STIP1
Novelty: 0.00590952
p_int: 0.937972169
p_ni: 0.062027831
Score: 0.158
Data Source: BioPlex,STRINGDB
DDRGK1
Novelty: 0.10774064
p_int: 0.866627675
p_ni: 0.133372325
Score: 0.175
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (10)
Reactome (3)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | Detoxification of Reactive Oxygen Species | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Detoxification of Reactive Oxygen Species | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (6)
Components (3)
Processes (12)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | NADPH oxidase 5 | 748494 | ||||||
Macaque | NADPH oxidase 5 [Source:HGNC Symbol;Acc:HGNC:14874] | |||||||
Dog | NADPH oxidase 5 | VGNC:43906 | 487620 | |||||
Horse | NADPH oxidase 5 | 100034218 | ||||||
Cow | NADPH oxidase 5 | VGNC:32185 | 531303 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | NADPH oxidase 5 | |||||
Macaque | NADPH oxidase 5 [Source:HGNC Symbol;Acc:HGNC:14874] | |||||
Dog | NADPH oxidase 5 | |||||
Horse | NADPH oxidase 5 | |||||
Cow | NADPH oxidase 5 | |||||
Publication Statistics
PubMed Score 159.35
PubMed score by year
PubTator Score 97.63
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (71)
GeneRif Annotations (61)
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