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Tchem
NOX5
NADPH oxidase 5

Protein Summary
Description
Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin. This gene is predominantly expressed in the testis and lymphocyte-rich areas of spleen and lymph nodes. It encodes a calcium-dependen NADPH oxidase that generates superoxide, and functions as a calcium-dependent proton channel that may regulate redox-dependent processes in lymphocytes and spermatozoa. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260364
  • ENSP00000454143
  • ENSG00000255346
  • ENST00000388866
  • ENSP00000373518
  • ENST00000448182
  • ENSP00000410887
  • ENST00000455873
  • ENSP00000416828
  • ENST00000530406
  • ENSP00000432440
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.97
cell type or tissue
0.78
tissue
0.73
kinase
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.35   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 223   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.35   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 17
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (42)
MTHFR
Tbio
Family:  Enzyme
Novelty:  0.00018162
p_int:  0.999556456
p_ni:  0.000443544
Score:  0.202
Data Source:  BioPlex,STRINGDB
GUCY1B1
Tclin
Family:  Enzyme
Novelty:  0.03618378
p_int:  0.999502657
p_ni:  0.000497262
p_wrong:  8.2e-8
Score:  0.38
Data Source:  BioPlex,STRINGDB
PDP2
Tbio
Family:  Enzyme
Novelty:  0.0259516
p_int:  0.991203791
p_ni:  0.000555628
p_wrong:  0.008240581
Score:  0.245
Data Source:  BioPlex,STRINGDB
TTC4
Tbio
Novelty:  0.00808711
p_int:  0.975771114
p_ni:  0.024228886
Score:  0.243
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.965457606
p_ni:  0.034542394
Score:  0.217
Data Source:  BioPlex,STRINGDB
PRKAR1B
Tbio
Family:  Enzyme
Novelty:  0.05355517
p_int:  0.944362699
p_ni:  0.055637301
Score:  0.186
Data Source:  BioPlex,STRINGDB
STIP1
Tbio
Novelty:  0.00590952
p_int:  0.937972169
p_ni:  0.062027831
Score:  0.158
Data Source:  BioPlex,STRINGDB
DDRGK1
Tbio
Novelty:  0.10774064
p_int:  0.866627675
p_ni:  0.133372325
Score:  0.175
Data Source:  BioPlex,STRINGDB
CYBA
Tbio
Novelty:  0.00177762
Score:  0.871
Data Source:  STRINGDB
NCF2
Tbio
Novelty:  0.00274685
Score:  0.853
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Cellular responses to external stimuli (R-HSA-8953897)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Detoxification of Reactive Oxygen Species
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
Detoxification of Reactive Oxygen Species
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADPH oxidase 5
748494
Macaque
NADPH oxidase 5 [Source:HGNC Symbol;Acc:HGNC:14874]
Dog
NADPH oxidase 5
VGNC:43906
487620
Horse
NADPH oxidase 5
100034218
Cow
NADPH oxidase 5
VGNC:32185
531303
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADPH oxidase 5
Macaque
NADPH oxidase 5 [Source:HGNC Symbol;Acc:HGNC:14874]
Dog
NADPH oxidase 5
Horse
NADPH oxidase 5
Cow
NADPH oxidase 5
Publication Statistics
PubMed Score 159.35
PubMed score by year
PubTator Score 97.63
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title