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Tbio
Q96PG8
Bcl-2-binding component 3

Protein Summary
Description
Isoform 3: Does not affect cell growth. This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300880
  • ENSP00000300880
  • ENSG00000105327
  • ENST00000449228
  • ENSP00000404503

Symbol
  • PUMA
  • JFY1
  • PUMA
  • JFY-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.79   (req: < 5)
Gene RIFs: 169   (req: <= 3)
Antibodies: 746   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.79   (req: >= 5)
Gene RIFs: 169   (req: > 3)
Antibodies: 746   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
BCL2
Tclin
Novelty:  0.00608635
p_int:  0.99999849
p_ni:  0.000001509
p_wrong:  1e-9
Score:  0.972
Data Source:  BioPlex,STRINGDB
BCL2L1
Tchem
Novelty:  0.00018414
Score:  0.986
Data Source:  STRINGDB
MCL1
Tchem
Novelty:  0.00046181
Score:  0.984
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.978
Data Source:  STRINGDB
BCL2A1
Tchem
Novelty:  0.00088899
Score:  0.976
Data Source:  STRINGDB
PMAIP1
Tbio
Novelty:  0.00198406
Score:  0.972
Data Source:  STRINGDB
BID
Tbio
Novelty:  0.01264688
Score:  0.956
Data Source:  STRINGDB
BCL2L11
Tchem
Novelty:  0.00055914
Score:  0.937
Data Source:  STRINGDB
TP73
Tbio
Family:  TF
Novelty:  0.00667737
Score:  0.926
Data Source:  STRINGDB
TP53BP2
Tbio
Novelty:  0.01058379
Score:  0.925
Data Source:  STRINGDB
Pathways (34)
Activation of BH3-only proteins (R-HSA-114452)

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Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of BH3-only proteins
Reactome
Activation of PUMA and translocation to mitochondria
Reactome
Apoptosis
Reactome
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Reactome
FOXO-mediated transcription
Name
Explore in Pharos
Explore in Source
Activation of BH3-only proteins
Activation of PUMA and translocation to mitochondria
Apoptosis
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
FOXO-mediated transcription
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
3
6
95.5
leukocyte count
2
3
6
82
monocyte count
2
2
4
78.7
myeloid white cell count
1
1
2
75.7
appendicular lean mass
1
1
2
59.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
6
95.5
leukocyte count
6
82
monocyte count
4
78.7
myeloid white cell count
2
75.7
appendicular lean mass
2
59.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BCL2 binding component 3
VGNC:2097
746617
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BCL2 binding component 3
Publication Statistics
PubMed Score 106.79
PubMed score by year
PubTator Score 19.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title