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Tchem
TSSK2
Testis-specific serine/threonine-protein kinase 2

Protein Summary
Description
Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at 'Ser-288' and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. TSSK2 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399635
  • ENSP00000382544
  • ENSG00000206203

Symbol
  • DGSG
  • SPOGA2
  • STK22B
  • TSK2
  • DGS-G
  • SPOGA2
  • STK22B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
molecular function
0.95
gene perturbation
0.78
protein domain
0.73
cellular component
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.35   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.35   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL2151321
chemical structure image
Pathways (5)
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
22q11.2 Deletion Syndrome
WikiPathways
22q11.2 Deletion Syndrome
WikiPathways
22q11.2 Deletion Syndrome
WikiPathways
22q11.2 Deletion Syndrome
WikiPathways
Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms
Name
Explore in Pharos
Explore in Source
22q11.2 Deletion Syndrome
22q11.2 Deletion Syndrome
22q11.2 Deletion Syndrome
22q11.2 Deletion Syndrome
Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms
Protein-Protein Interactions (20)
1 – 10 of 20
TSKS
Tbio
Family: Enzyme
Novelty: 0.0886446
Score: 0.768
Data Source: STRINGDB
ZP1
Tbio
Novelty: 0.16160314
Score: 0.546
Data Source: STRINGDB
TXN2
Tbio
Novelty: 0.0059799
Score: 0.522
Data Source: STRINGDB
ARMC3
Tbio
Novelty: 0.09818374
Score: 0.51
Data Source: STRINGDB
MOS
Tbio
Family: Kinase
Novelty: 0.05699356
Score: 0.505
Data Source: STRINGDB
ENKUR
Tdark
Novelty: 0.35703467
Score: 0.496
Data Source: STRINGDB
ODF3
Tbio
Novelty: 0.08747036
Score: 0.491
Data Source: STRINGDB
SIPA1L1
Tdark
Novelty: 0.13134052
Score: 0.484
Data Source: STRINGDB
PACRG
Tbio
Novelty: 0.01879528
Score: 0.478
Data Source: STRINGDB
PKMYT1
Tchem
Family: Kinase
Novelty: 0.03025516
Score: 0.473
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.35

PubMed score by year
PubTator Score  10.84

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer