Tbio MCEE Methylmalonyl-CoA epimerase, mitochondrial

Protein Summary

Description

The product of this gene catalyzes the interconversion of D- and L-methylmalonyl-CoA during the degradation of branched chain amino acids. odd chain-length fatty acids, and other metabolites. Mutations in this gene result in methylmalonyl-CoA epimerase deficiency, which is presented as mild to moderate methylmalonic aciduria. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96PE7
• Q53TP1
• Q8WW63

Gene Name

• MCEE

Ensembl ID

• ENST00000244217
• ENSP00000244217
• ENSG00000124370

Symbol

• GLOD2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.92
disease perturbation	0.9
transcription factor perturbation	0.8
tissue sample	0.72
transcription factor binding site profile	0.72

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Glycosylase / Methylmalonyl-coa Epimerase, Mitochondrial

DTO Classes

Protein / Enzyme / Hydrolase / Glycosylase / Dna Glycosylase / Methylmalonyl-coa Epimerase, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.55   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 156   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.55   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0