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Tbio
INPP4A
Type I inositol 3,4-bisphosphate 4-phosphatase

Protein Summary
Description
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-bisphosphate. This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Aug 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000074304
  • ENSP00000074304
  • ENSG00000040933
  • ENST00000409016
  • ENSP00000386704
  • ENST00000409540
  • ENSP00000387294
  • ENST00000409851
  • ENSP00000386777
  • ENST00000523221
  • ENSP00000427722

Symbol
  • INPP4
  • TVAS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
small molecule perturbation
0.87
disease perturbation
0.79
transcription factor binding site profile
0.69
transcription factor
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.46   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.46   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metastatic colorectal cancer
1
1
0
2.1
21.5
progression free survival
1
1
0
2.1
21.5
response to CAPOX-B
1
1
0
2.1
21.5
response to cetuximab
1
1
0
2.1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
metastatic colorectal cancer
0
2.1
21.5
progression free survival
0
2.1
21.5
response to CAPOX-B
0
2.1
21.5
response to cetuximab
0
2.1
21.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inositol polyphosphate-4-phosphatase type I A
470448
Macaque
inositol polyphosphate-4-phosphatase type I A
707986
Mouse
MGI:1931123
269180
Rat
RGD:68386
80849
Dog
inositol polyphosphate-4-phosphatase type I A
VGNC:42028
474563
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inositol polyphosphate-4-phosphatase type I A
Macaque
inositol polyphosphate-4-phosphatase type I A
Mouse
Rat
Dog
inositol polyphosphate-4-phosphatase type I A
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96PE3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (99)
Inositol phosphate metabolism (R-HSA-1483249)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Gene Ontology Terms (9)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (54)
1 – 10 of 54
NXT2
Tdark
Novelty:  0.03767394
p_int:  1
Score:  0.379
Data Source:  BioPlex,STRINGDB
WDYHV1
Tbio
Family:  Enzyme
Novelty:  0.1844203
p_int:  0.999945677
p_ni:  0.000025828
p_wrong:  0.000028495
Score:  0.189
Data Source:  BioPlex,STRINGDB
INPP5B
Tbio
Family:  Enzyme
Novelty:  0.02981249
Score:  0.959
Data Source:  STRINGDB
INPP5J
Tbio
Family:  Enzyme
Novelty:  0.0537284
Score:  0.958
Data Source:  STRINGDB
OCRL
Tbio
Family:  Enzyme
Novelty:  0.00555539
Score:  0.957
Data Source:  STRINGDB
INPPL1
Tchem
Family:  Enzyme
Novelty:  0.00634126
Score:  0.955
Data Source:  STRINGDB
SYNJ1
Tchem
Novelty:  0.01030746
Score:  0.95
Data Source:  STRINGDB
INPP5K
Tbio
Family:  Enzyme
Novelty:  0.07282504
Score:  0.95
Data Source:  STRINGDB
INPP5A
Tchem
Family:  Enzyme
Novelty:  0.03249263
Score:  0.948
Data Source:  STRINGDB
INPP1
Tbio
Family:  Enzyme
Novelty:  0.05426301
Score:  0.946
Data Source:  STRINGDB
Publication Statistics
PubMed Score  27.46

PubMed score by year
PubTator Score  7.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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