Tbio ADGRA2 Adhesion G protein-coupled receptor A2

Protein Summary

Description

Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628).

Uniprot Accession IDs

• Q96PE1
• A6H8W3
• D3DSW4
• Q8N3R1
• Q8TEM3
• Q96KB2
• Q9P1Z7
• Q9UFY4

Gene Name

• ADGRA2

Ensembl ID

• ENST00000315215
• ENSP00000323508
• ENSG00000020181
• ENST00000412232
• ENSP00000406367

Symbol

• GPR124
• KIAA1531
• TEM5
• TEM5
• GPR124

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
gene perturbation	0.87
PubMedID	0.82
microRNA	0.76
transcription factor binding site profile	0.64

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Adhesion Class / G-protein Coupled Receptor 124

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.08   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 297   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.08   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 297   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0