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Tbio
ADGRA2
Adhesion G protein-coupled receptor A2

Protein Summary
Description
Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315215
  • ENSP00000323508
  • ENSG00000020181
  • ENST00000412232
  • ENSP00000406367

Symbol
  • GPR124
  • KIAA1531
  • TEM5
  • TEM5
  • GPR124
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
gene perturbation
0.87
PubMedID
0.82
microRNA
0.76
transcription factor binding site profile
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.94   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 297   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.94   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 297   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (15)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
GDB
Protein-Protein Interactions (44)
1 – 10 of 44
ITGAV
Tchem
Novelty: 0.00217401
Score: 0.912
Data Source: STRINGDB
ITGB3
Tclin
Novelty: 0.00086996
Score: 0.902
Data Source: STRINGDB
ADGRL1
Tbio
Family: GPCR
Novelty: 0.01343585
Score: 0.755
Data Source: STRINGDB
DLG1
Tbio
Novelty: 0.00644048
Score: 0.749
Data Source: STRINGDB
ADGRL2
Tbio
Family: GPCR
Novelty: 0.01111728
Score: 0.739
Data Source: STRINGDB
ADGRL3
Tbio
Family: GPCR
Novelty: 0.00182297
Score: 0.728
Data Source: STRINGDB
PLXDC1
Tbio
Novelty: 0.0122883
Score: 0.709
Data Source: STRINGDB
ADGRF2
Tdark
Family: GPCR
Novelty: 1.76986065
Score: 0.636
Data Source: STRINGDB
NDP
Tbio
Novelty: 0.01137711
Score: 0.635
Data Source: STRINGDB
CD248
Tbio
Novelty: 0.00079399
Score: 0.631
Data Source: STRINGDB
Publication Statistics
PubMed Score  32.94

PubMed score by year
PubTator Score  21.5

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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