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Tchem
DGAT2
Diacylglycerol O-acyltransferase 2

Protein Summary
Description
Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides (PubMed:27184406). Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT). This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228027
  • ENSP00000228027
  • ENSG00000062282
  • ENST00000376262
  • ENSP00000365438

Symbol
  • ARAT
  • HMFN1045
  • GS1999FULL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
transcription factor perturbation
0.88
transcription factor binding site profile
0.84
histone modification site profile
0.83
biological process
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.58   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 280   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 199.58   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 191
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
2
2
2
92.8
red blood cell density measurement
1
1
1
68.4
high density lipoprotein cholesterol measurement
2
1
4
49.8
alcohol drinking
1
1
2
46.4
total cholesterol measurement
1
1
1
15.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
2
92.8
red blood cell density measurement
1
68.4
high density lipoprotein cholesterol measurement
4
49.8
alcohol drinking
2
46.4
total cholesterol measurement
1
15.6
Pathways (13)
Acyl chain remodeling of DAG and TAG (R-HSA-1482883)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodeling of DAG and TAG
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Acyl chain remodeling of DAG and TAG
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Gene Ontology Terms (30)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (148)
1 – 10 of 148
DGAT1
Tclin
Family: Enzyme
Novelty: 0.00121009
Score: 0.992
Data Source: STRINGDB
PLPP2
Tbio
Family: Enzyme
Novelty: 0.09824135
Score: 0.941
Data Source: STRINGDB
PLPP1
Tbio
Family: Enzyme
Novelty: 0.06521084
Score: 0.927
Data Source: STRINGDB
PLPP3
Tbio
Family: Enzyme
Novelty: 0.01655047
Score: 0.918
Data Source: STRINGDB
PLPPR2
Tdark
Family: Enzyme
Novelty: 1.03318406
Score: 0.916
Data Source: STRINGDB
PLPP4
Tbio
Family: Enzyme
Novelty: 0.22418589
Score: 0.915
Data Source: STRINGDB
PLPP5
Tbio
Family: Enzyme
Novelty: 0.14757412
Score: 0.915
Data Source: STRINGDB
MOGAT1
Tbio
Family: Enzyme
Novelty: 0.0503068
Score: 0.907
Data Source: STRINGDB
PLPPR4
Tbio
Family: Enzyme
Novelty: 0.04514953
Score: 0.906
Data Source: STRINGDB
MOGAT2
Tchem
Family: Enzyme
Novelty: 0.06314447
Score: 0.906
Data Source: STRINGDB
Publication Statistics
PubMed Score  199.58

PubMed score by year
PubTator Score  67.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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