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Tchem
DGAT2
Diacylglycerol O-acyltransferase 2

Protein Summary
Description
Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides (PubMed:27184406). Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT). This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228027
  • ENSP00000228027
  • ENSG00000062282
  • ENST00000376262
  • ENSP00000365438

Symbol
  • ARAT
  • HMFN1045
  • GS1999FULL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
transcription factor perturbation
0.88
transcription factor binding site profile
0.84
histone modification site profile
0.83
biological process
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.21   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 280   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.21   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 196
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (196)
1 – 10 of 196
CHEMBL3734797
Rendered image for CHEMBL3734797
CHEMBL2178953
Rendered image for CHEMBL2178953
CHEMBL3736366
Rendered image for CHEMBL3736366
CHEMBL3736092
Rendered image for CHEMBL3736092
CHEMBL3734770
Rendered image for CHEMBL3734770
CHEMBL4098964,CHEMBL4278523
Rendered image for CHEMBL4098964,CHEMBL4278523
US9296745, 1
Rendered image for US9296745, 1
US9296745, 199
Rendered image for US9296745, 199
US9296745, 2
Rendered image for US9296745, 2
US9296745, 108
Rendered image for US9296745, 108
Protein-Protein Interactions (148)
1 – 10 of 148
DGAT1
Tclin
Family:  Enzyme
Novelty:  0.00121009
Score:  0.992
Data Source:  STRINGDB
PLPP2
Tbio
Family:  Enzyme
Novelty:  0.09824135
Score:  0.941
Data Source:  STRINGDB
PLPP1
Tbio
Family:  Enzyme
Novelty:  0.06521084
Score:  0.927
Data Source:  STRINGDB
PLPP3
Tbio
Family:  Enzyme
Novelty:  0.01655047
Score:  0.918
Data Source:  STRINGDB
PLPPR2
Tdark
Family:  Enzyme
Novelty:  1.03318406
Score:  0.916
Data Source:  STRINGDB
PLPP4
Tbio
Family:  Enzyme
Novelty:  0.22418589
Score:  0.915
Data Source:  STRINGDB
PLPP5
Tbio
Family:  Enzyme
Novelty:  0.14757412
Score:  0.915
Data Source:  STRINGDB
MOGAT1
Tbio
Family:  Enzyme
Novelty:  0.0503068
Score:  0.907
Data Source:  STRINGDB
PLPPR4
Tbio
Family:  Enzyme
Novelty:  0.04514953
Score:  0.906
Data Source:  STRINGDB
MOGAT2
Tchem
Family:  Enzyme
Novelty:  0.06314447
Score:  0.906
Data Source:  STRINGDB
Pathways (13)
Acyl chain remodeling of DAG and TAG (R-HSA-1482883)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodeling of DAG and TAG
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Acyl chain remodeling of DAG and TAG
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Gene Ontology Terms (30)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
9
7
12
97.1
apolipoprotein A 1 measurement
2
2
2
89
hemoglobin measurement
3
3
3
83.6
vitamin D measurement
3
3
3
78.5
alkaline phosphatase measurement
2
2
1
5.8
70.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
12
97.1
apolipoprotein A 1 measurement
2
89
hemoglobin measurement
3
83.6
vitamin D measurement
3
78.5
alkaline phosphatase measurement
1
5.8
70.9
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
diacylglycerol O-acyltransferase 2
VGNC:3134
466714
Macaque
diacylglycerol O-acyltransferase 2
696549
Mouse
MGI:1915050
67800
Rat
RGD:620329
252900
Dog
diacylglycerol O-acyltransferase 2
VGNC:39913
485185
Species
Name
OMA
EggNOG
Inparanoid
Chimp
diacylglycerol O-acyltransferase 2
Macaque
diacylglycerol O-acyltransferase 2
Mouse
Rat
Dog
diacylglycerol O-acyltransferase 2
Publication Statistics
PubMed Score 207.21
PubMed score by year
PubTator Score 67.82
PubTator score by year