You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MOGAT1
2-acylglycerol O-acyltransferase 1

Protein Summary
Description
Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine (By similarity). Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerols, the precursor of physiologically important lipids such as triacylglycerol and phospholipids (Yen et al., 2002 [PubMed 12077311]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000446656
  • ENSP00000406674
  • ENSG00000124003

Symbol
  • DC2
  • DGAT2L1
  • MGAT1
  • DGAT2L
  • DGAT2L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
histone modification site profile
0.69
cell type or tissue
0.68
gene perturbation
0.6
cell line
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.19   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.19   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
DGAT1
Tclin
Family:  Enzyme
Novelty:  0.00121009
Score:  0.995
Data Source:  STRINGDB
PLPP2
Tbio
Family:  Enzyme
Novelty:  0.09824135
Score:  0.977
Data Source:  STRINGDB
PLPP1
Tbio
Family:  Enzyme
Novelty:  0.06521084
Score:  0.959
Data Source:  STRINGDB
MGLL
Tchem
Family:  Enzyme
Novelty:  0.00196912
Score:  0.941
Data Source:  STRINGDB
LPL
Tchem
Family:  Enzyme
Novelty:  0.00057058
Score:  0.919
Data Source:  STRINGDB
PLPP5
Tbio
Family:  Enzyme
Novelty:  0.14757412
Score:  0.915
Data Source:  STRINGDB
PLPP4
Tbio
Family:  Enzyme
Novelty:  0.22418589
Score:  0.915
Data Source:  STRINGDB
PLPP3
Tbio
Family:  Enzyme
Novelty:  0.01655047
Score:  0.912
Data Source:  STRINGDB
AGK
Tbio
Family:  Enzyme
Novelty:  0.00919083
Score:  0.91
Data Source:  STRINGDB
DGAT2
Tchem
Family:  Enzyme
Novelty:  0.00488581
Score:  0.907
Data Source:  STRINGDB
Pathways (8)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Triglyceride biosynthesis
Reactome
Triglyceride metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Triglyceride biosynthesis
Triglyceride metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chin morphology measurement
1
1
0
1.2
21.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chin morphology measurement
0
1.2
21.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
monoacylglycerol O-acyltransferase 1
705924
Mouse
MGI:1915643
68393
Dog
monoacylglycerol O-acyltransferase 1
VGNC:43308
488548
Horse
monoacylglycerol O-acyltransferase 1
VGNC:20255
100056612
Cow
monoacylglycerol O-acyltransferase 1
VGNC:31550
407225
Species
Name
OMA
EggNOG
Inparanoid
Macaque
monoacylglycerol O-acyltransferase 1
Mouse
Dog
monoacylglycerol O-acyltransferase 1
Horse
monoacylglycerol O-acyltransferase 1
Cow
monoacylglycerol O-acyltransferase 1
Publication Statistics
PubMed Score 22.19
PubMed score by year
PubTator Score 63.61
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title