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Tbio
IL17F
Interleukin-17F

Protein Summary
Description
Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover (PubMed:11591732, PubMed:11591768, PubMed:11574464). Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis (PubMed:11591732). Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation (By similarity). The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and ind ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336123
  • ENSP00000337432
  • ENSG00000112116

Symbol
  • ML1
  • ML-1
  • CANDF6
  • IL-17F
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.75
biological process
0.74
trait
0.61
disease
0.49
phenotype
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 283.56   (req: < 5)
Gene RIFs: 168   (req: <= 3)
Antibodies: 776   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 283.56   (req: >= 5)
Gene RIFs: 168   (req: > 3)
Antibodies: 776   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (53)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-17 signaling
Reactome
Interleukin-4 and Interleukin-13 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-17 signaling
Interleukin-4 and Interleukin-13 signaling
Signaling by Interleukins
Protein-Protein Interactions (142)
1 – 10 of 142
VCAN
Tbio
Novelty: 0.00132314
p_int: 0.999991361
p_ni: 0.000008633
p_wrong: 6e-9
Data Source: BioPlex
TMEM159
Tdark
Novelty: 0.36363636
p_int: 0.998757455
p_ni: 0.00023319
p_wrong: 0.001009355
Data Source: BioPlex
HMGCS1
Tchem
Family: Enzyme
Novelty: 0.01850134
p_int: 0.998571666
p_ni: 0.001426859
p_wrong: 0.000001475
Data Source: BioPlex
MCRIP2
Tdark
Novelty: 5
p_int: 0.998503522
p_ni: 0.001318874
p_wrong: 0.000177604
Data Source: BioPlex
C20orf141
Tdark
p_int: 0.998503522
p_ni: 0.001318874
p_wrong: 0.000177604
Data Source: BioPlex
SDHD
Tbio
Family: Enzyme
Novelty: 0.00222227
p_int: 0.998047936
p_ni: 0.00139865
p_wrong: 0.000553414
Data Source: BioPlex
PRKCI
Tchem
Family: Kinase
Novelty: 0.01104604
p_int: 0.997190479
p_ni: 0.00280952
p_wrong: 1e-9
Data Source: BioPlex
VWDE
Tdark
Novelty: 0.7751938
p_int: 0.99625355
p_ni: 0.003447228
p_wrong: 0.000299221
Data Source: BioPlex
C1GALT1C1
Tbio
Family: Enzyme
Novelty: 0.00694171
p_int: 0.994814556
p_ni: 0.005185444
Data Source: BioPlex
SQSTM1
Tbio
Novelty: 0.0013045
p_int: 0.94672289
p_ni: 0.05327711
Data Source: BioPlex
Publication Statistics
PubMed Score  283.56

PubMed score by year
PubTator Score  970.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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