Tbio MIA2 Melanoma inhibitory activity protein 2

Protein Summary

Description

Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. Isoform 1 plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). This gene encodes s receptor in the endoplasmic reticulum, which plays a role in the export of large pre-chylomicrons and pre-very low density lipoproteins (pre-VLDLs). Three major classes of transcripts are generated from this gene- melanoma inhibitory activity 2-specific transcripts, cTAGE family member 5-specific transcripts and transcripts that include exons from both these transcript species (TANGO1-like or TALI). Additionally, alternative splicing in these transcripts results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Sep 2016]

Uniprot Accession IDs

• Q96PC5
• A1L4H0
• Q9H6C1

Gene Name

• MIA2

Ensembl ID

• ENST00000280082
• ENSP00000280082
• ENSG00000150527
• ENST00000640607
• ENSP00000491014

Symbol

• MEA6
• MGEA
• TALI
• MGEA6
• CTAGE5
• MGEA11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	0.83
disease perturbation	0.79
transcription factor binding site profile	0.73
transcription factor	0.71
cell type or tissue	0.68

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Growth Factor / Melanoma Inhibitory Activity Protein 2

DTO Classes

Protein / Signaling / Growth Factor / Melanoma Inhibitory Activity Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.41   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 119   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.41   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0