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Tbio
AP1S3
AP-1 complex subunit sigma-3

Protein Summary
Description
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Involved in TLR3 trafficking (PubMed:24791904). This gene encodes a member of the adaptor-related protein complex 1, sigma subunit genes. The encoded protein is a component of adaptor protein complex 1 (AP-1), one of the AP complexes involved in claathrin-mediated vesicular transport from the Golgi or endosomes. Disruption of the pathway for display of HIV-1 antigens, which prevents recognition of the virus by cytotoxic T cells, has been shown to involve the AP-1 complex (PMID: 15569716). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396654
  • ENSP00000379891
  • ENSG00000152056
  • ENST00000415298
  • ENSP00000401705
  • ENST00000443700
  • ENSP00000397155
  • ENST00000446015
  • ENSP00000388738

Symbol
  • PSORS15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.83
gene perturbation
0.74
cellular component
0.73
cell type or tissue
0.72
virus perturbation
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.59   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 96   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.59   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
childhood onset asthma
1
1
0
1.1
44
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
childhood onset asthma
0
1.1
44
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 1 subunit sigma 3
VGNC:73
459979
Macaque
adaptor related protein complex 1 sigma 3 subunit
710257
Mouse
MGI:1891304
252903
Rat
RGD:1311772
367304
Dog
adaptor related protein complex 1 subunit sigma 3
VGNC:37957
478929
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 1 subunit sigma 3
Macaque
adaptor related protein complex 1 sigma 3 subunit
Mouse
Rat
Dog
adaptor related protein complex 1 subunit sigma 3
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96PC3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Disease
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
HIV Infection
Reactome
Host Interactions of HIV factors
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Disease
Golgi Associated Vesicle Biogenesis
HIV Infection
Host Interactions of HIV factors
Gene Ontology Terms (12)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (129)
1 – 10 of 129
AFTPH
Tbio
Novelty: 0.21887849
p_int: 0.999999991
p_ni: 6e-9
p_wrong: 3e-9
Score: 0.552
Data Source: BioPlex,STRINGDB
KIF13A
Tbio
Novelty: 0.04988003
p_int: 0.99999999
p_ni: 9e-9
Data Source: BioPlex
AP1AR
Tbio
Novelty: 0.01660994
p_int: 0.999999969
p_ni: 1e-9
p_wrong: 3e-8
Data Source: BioPlex
SYNRG
Tdark
Novelty: 0.03621564
p_int: 0.999999967
p_ni: 3.3e-8
Data Source: BioPlex
HEATR5B
Tdark
Novelty: 3.21111035
p_int: 0.999999914
p_ni: 3.4e-8
p_wrong: 5.2e-8
Data Source: BioPlex
AP2M1
Tbio
Novelty: 0.00769368
p_int: 0.99999893
p_ni: 5.4e-8
p_wrong: 0.000001016
Score: 0.625
Data Source: BioPlex,STRINGDB
AP1G2
Tbio
Novelty: 0.17203425
p_int: 0.999995206
p_ni: 0.000004793
Score: 0.919
Data Source: BioPlex,STRINGDB
AP1B1
Tbio
Novelty: 0.03370208
p_int: 0.999994747
p_ni: 0.000005253
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
AP1G1
Tbio
Novelty: 0.03754132
p_int: 0.999994179
p_ni: 0.000005821
Score: 0.99
Data Source: BioPlex,Reactome,STRINGDB
AP1M1
Tbio
Novelty: 0.029282
p_int: 0.999983873
p_ni: 0.000016127
Score: 0.971
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  6.59

PubMed score by year
PubTator Score  2.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer