Tbio AP1S3 AP-1 complex subunit sigma-3

Protein Summary

Description

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Involved in TLR3 trafficking (PubMed:24791904). This gene encodes a member of the adaptor-related protein complex 1, sigma subunit genes. The encoded protein is a component of adaptor protein complex 1 (AP-1), one of the AP complexes involved in claathrin-mediated vesicular transport from the Golgi or endosomes. Disruption of the pathway for display of HIV-1 antigens, which prevents recognition of the virus by cytotoxic T cells, has been shown to involve the AP-1 complex (PMID: 15569716). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Uniprot Accession IDs

• Q96PC3
• B4DQZ1
• Q8WTY1
• Q96DD1

Gene Name

• AP1S3

Ensembl ID

• ENST00000396654
• ENSP00000379891
• ENSG00000152056
• ENST00000415298
• ENSP00000401705
• ENST00000443700
• ENSP00000397155
• ENST00000446015
• ENSP00000388738

Symbol

• PSORS15

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.83
gene perturbation	0.74
cellular component	0.73
cell type or tissue	0.72
virus perturbation	0.72

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Vesicle Coat Protein / Ap-1 Complex Subunit Sigma-3

DTO Classes

Protein / Transporter / Vesicle Coat Protein / Ap-1 Complex Subunit Sigma-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.83   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 96   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.83   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 96   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0