LRRC3B
Leucine-rich repeat-containing protein 3B
Protein Summary
The protein encoded by this gene is a tumor suppressor, with lowered expression levels found in gastric, renal, colorectal, lung, and breast cancer tissues. The promoter of this gene is frequently hypermethylated in these cancer tissues, although the hypermethylation does not appear to be the cause of the reduced expression of this gene. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]
- ENST00000396641
- ENSP00000379880
- ENSG00000179796
- ENST00000417744
- ENSP00000406370
- ENST00000456208
- ENSP00000394940
- ENST00000648296
- ENSP00000497471
- LRP15
- LRP15
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.81 | ||
cell type or tissue | 0.55 | ||
phenotype | 0.51 | ||
PubMedID | 0.51 | ||
disease | 0.47 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.4 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 93 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 20.4 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 93 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 0
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0