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Tbio
IPO9
Importin-9

Protein Summary
Description
Functions in nuclear protein import as nuclear transport receptor (PubMed:11823430). Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11823430). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11823430). At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran (PubMed:11823430). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11823430). Mediates the nuclear import of RPS7, RPL18A, RPL6, histone H2A, histone H2B and histone (PubMed:11823430). Prevents the cytoplasmic aggregation of RPS7 ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
disease perturbation
0.97
kinase perturbation
0.91
transcription factor perturbation
0.88
transcription factor binding site profile
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.9   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.9   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
3
4
99.3
visceral adipose tissue measurement
1
1
1
90.5
cognitive function measurement
1
1
1
69.5
1
1
1
69.2
waist circumference
1
1
1
61.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
99.3
visceral adipose tissue measurement
1
90.5
cognitive function measurement
1
69.5
1
69.2
waist circumference
1
61.7
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
importin 9
VGNC:10669
457623
Macaque
importin 9
707210
Mouse
MGI:1918944
226432
Rat
RGD:1310537
304817
Dog
importin 9
VGNC:42069
480004
Species
Name
OMA
EggNOG
Inparanoid
Chimp
importin 9
Macaque
importin 9
Mouse
Rat
Dog
importin 9
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96P70-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (101)
1 – 10 of 101
H2AFX
Tbio
Novelty: 0.00048694
p_int: 0.999996262
p_ni: 0.000003738
Score: 0.291
Data Source: BioPlex,STRINGDB
H2AFZ
Tbio
Novelty: 0.00222512
p_int: 0.999972641
p_ni: 0.000027359
Score: 0.507
Data Source: BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty: 0.02431803
p_int: 0.999856357
p_ni: 0.000143643
Score: 0.32
Data Source: BioPlex,STRINGDB
SIGLECL1
Tdark
p_int: 0.999846311
p_ni: 0.000153689
Data Source: BioPlex
H2AFY2
Tbio
Novelty: 0.09948698
p_int: 0.999402564
p_ni: 0.000597436
Score: 0.297
Data Source: BioPlex,STRINGDB
TMEM206
Tdark
Novelty: 0.17311172
p_int: 0.999279103
p_ni: 0.000720897
Data Source: BioPlex
AKIRIN2
Tbio
Novelty: 0.04603317
p_int: 0.997319269
p_ni: 0.002680731
Score: 0.22
Data Source: BioPlex,STRINGDB
VTI1B
Tbio
Novelty: 0.00955467
p_int: 0.991939677
p_ni: 0.008060323
Score: 0.62
Data Source: BioPlex,STRINGDB
TPST2
Tbio
Family: Enzyme
Novelty: 0.02551048
p_int: 0.9915623
p_ni: 0.0084377
Data Source: BioPlex
PTGER3
Tclin
Family: GPCR
Novelty: 0.0012681
p_int: 0.989879533
p_ni: 0.010120467
Data Source: BioPlex
Publication Statistics
PubMed Score  21.90

PubMed score by year
PubTator Score  10.48

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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