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Tdark
AGAP4
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4

Protein Summary
Description
Putative GTPase-activating protein.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000448048
  • ENSP00000392513
  • ENSG00000188234

Symbol
  • AGAP8
  • CTGLF1
  • CTGLF5
  • MRIP2
  • AGAP8
  • MRIP2
  • AGAP-4
  • AGAP-8
  • CTGLF1
  • CTGLF5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
tissue
0.7
tissue sample
0.69
cell type or tissue
0.61
cellular component
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.07   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.07   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (11)
LDAH
Tbio
Family:  Enzyme
Novelty:  0.0951829
Score:  0.587
Data Source:  STRINGDB
ANKRD31
Tdark
Novelty:  0.5338446
Score:  0.532
Data Source:  STRINGDB
ZNF620
Tdark
Family:  TF
Novelty:  2.57179565
Score:  0.514
Data Source:  STRINGDB
GRAMD1A
Tbio
Novelty:  0.15461113
Score:  0.51
Data Source:  STRINGDB
HDHD3
Tdark
Family:  Enzyme
Novelty:  0.51499634
Score:  0.477
Data Source:  STRINGDB
AHDC1
Tdark
Novelty:  0.06647774
Score:  0.473
Data Source:  STRINGDB
CXorf36
Tdark
Novelty:  0.39667071
Score:  0.453
Data Source:  STRINGDB
ZPLD1
Tbio
Novelty:  0.19418088
Score:  0.446
Data Source:  STRINGDB
RFX6
Tbio
Family:  TF
Novelty:  0.02967745
Score:  0.444
Data Source:  STRINGDB
PLEKHS1
Tbio
Novelty:  0.23671821
Score:  0.422
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
82.7
red blood cell density measurement
1
1
1
59
neutrophil count
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
82.7
red blood cell density measurement
1
59
neutrophil count
1
30.2
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 2.07
PubMed score by year
PubTator Score 6.40
PubTator score by year
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Related Publications
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PMID
Year
Title