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Tbio
SERPINB12
Serpin B12

Protein Summary
Description
Inhibits trypsin and plasmin, but not thrombin, coagulation factor Xa, or urokinase-type plasminogen activator.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269491
  • ENSP00000269491
  • ENSG00000166634
  • ENST00000382768
  • ENSP00000372218

Symbol
  • YUKOPIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.63
cell type or tissue
0.55
cell line
0.54
tissue
0.54
protein complex
0.45


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.22   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.22   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
1
1
1
2.5
eosinophil percentage of leukocytes
1
1
1
2.4
sum of eosinophil and basophil counts
1
1
1
1.5
eosinophil percentage of granulocytes
1
1
1
1.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
1
2.5
eosinophil percentage of leukocytes
1
2.4
sum of eosinophil and basophil counts
1
1.5
eosinophil percentage of granulocytes
1
1.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serpin family B member 12
VGNC:9952
468567
Macaque
serpin family B member 12
700970
Mouse
MGI:1919119
71869
Rat
RGD:1566382
304692
Dog
serpin family B member 12
VGNC:46028
100687047
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serpin family B member 12
Macaque
serpin family B member 12
Mouse
Rat
Dog
serpin family B member 12
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (21)
1 – 10 of 21
DSC1
Tbio
Novelty: 0.01434802
Score: 0.6
Data Source: STRINGDB
KPRP
Tdark
Novelty: 0.11744927
Score: 0.594
Data Source: STRINGDB
DSG1
Tbio
Novelty: 0.00142889
Score: 0.578
Data Source: STRINGDB
IQCH
Tdark
Novelty: 0.47951177
Score: 0.531
Data Source: STRINGDB
UBQLN3
Tdark
Novelty: 0.25889138
Score: 0.515
Data Source: STRINGDB
KRTDAP
Tdark
Novelty: 0.12206865
Score: 0.508
Data Source: STRINGDB
SPRR4
Tdark
Novelty: 0.25132059
Score: 0.492
Data Source: STRINGDB
PKD2L2
Tbio
Family: IC
Novelty: 0.12399184
Score: 0.484
Data Source: STRINGDB
SERPINF2
Tbio
Novelty: 0.00054719
Score: 0.483
Data Source: STRINGDB
AHCYL1
Tchem
Family: Enzyme
Novelty: 0.02176432
Score: 0.47
Data Source: STRINGDB
Publication Statistics
PubMed Score  5.22

PubMed score by year
PubTator Score  3.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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