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Tchem
CATSPER2
Cation channel sperm-associated protein 2

Protein Summary
Description
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. This gene encodes a member of a family of cation channel proteins that localize to the flagellum of spermatozoa. Defects at this locus causes male infertility. Alternatively spliced transcript variants have been observed at this locus. Readthrough transcription originates upstream of this locus in diphosphoinositol pentakisphosphate kinase 1 pseudogene 1 and is represented by GeneID:110006325. Related pseudogenes are found next to this locus on chromosome 15 and on chromosome 5. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321596
  • ENSP00000321463
  • ENSG00000166762
  • ENST00000396879
  • ENSP00000380088
  • ENST00000433380
  • ENSP00000389746
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
cell type or tissue
0.78
cellular component
0.7
tissue sample
0.67
cell line
0.53


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.05   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.05   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
71.3
high density lipoprotein cholesterol measurement
1
1
1
68.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
71.3
high density lipoprotein cholesterol measurement
1
68.5
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cation channel sperm associated 2
710876
Mouse
MGI:2387404
212670
Rat
RGD:1307620
366174
Dog
cation channel sperm associated 2
VGNC:38745
609008
Horse
cation channel sperm associated 2
VGNC:16081
100070776
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cation channel sperm associated 2
Mouse
Rat
Dog
cation channel sperm associated 2
Horse
cation channel sperm associated 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96P56-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Fertilization (R-HSA-1187000)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fertilization
Reactome
Reproduction
Reactome
Sperm Motility And Taxes
Name
Explore in Pharos
Explore in Source
Fertilization
Reproduction
Sperm Motility And Taxes
Protein-Protein Interactions (74)
1 – 10 of 74
CATSPERG
Tdark
Novelty: 0.73161601
Score: 0.968
Data Source: Reactome,STRINGDB
STRC
Tbio
Novelty: 0.01587212
Score: 0.962
Data Source: STRINGDB
CATSPERD
Tdark
Novelty: 0.85066163
Score: 0.96
Data Source: Reactome,STRINGDB
CATSPER1
Tchem
Family: IC
Novelty: 0.01971564
Score: 0.955
Data Source: Reactome,STRINGDB
CATSPERB
Tdark
Novelty: 0.69373919
Score: 0.95
Data Source: Reactome,STRINGDB
CATSPER3
Tchem
Family: IC
Novelty: 0.09919608
Score: 0.936
Data Source: Reactome,STRINGDB
CATSPER4
Tchem
Family: IC
Novelty: 0.4554917
Score: 0.931
Data Source: Reactome,STRINGDB
CACNB4
Tbio
Family: IC
Novelty: 0.01564026
Score: 0.811
Data Source: STRINGDB
CACNB2
Tbio
Family: IC
Novelty: 0.01745218
Score: 0.81
Data Source: STRINGDB
CATSPERZ
Tdark
Novelty: 0.61619097
Score: 0.809
Data Source: STRINGDB
Publication Statistics
PubMed Score  25.05

PubMed score by year
PubTator Score  11.31

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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