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Tbio
ACAP3
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3

Protein Summary
Description
GTPase-activating protein for the ADP ribosylation factor family.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353662
  • ENSP00000321139
  • ENSG00000131584
  • ENST00000354700
  • ENSP00000346733

Symbol
  • CENTB5
  • KIAA1716
  • CENTB5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
transcription factor binding site profile
0.8
transcription factor
0.73
cell type or tissue
0.64
tissue sample
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.08   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.08   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (51)
1 – 10 of 51
ACAP2
Tbio
Novelty:  0.06711155
p_int:  0.999999907
p_wrong:  9.2e-8
Data Source:  BioPlex
SEPT10
Tbio
Novelty:  0.14834834
p_int:  0.99990544
p_ni:  0.000094557
p_wrong:  2e-9
Data Source:  BioPlex
SEPT5
Tbio
Novelty:  0.01670991
p_int:  0.999862652
p_ni:  0.000137348
Score:  0.338
Data Source:  BioPlex,STRINGDB
SEPT8
Tbio
Novelty:  0.01431499
p_int:  0.999779841
p_ni:  0.000220159
Data Source:  BioPlex
SEPT3
Tbio
Novelty:  0.008513
p_int:  0.999352327
p_ni:  0.000647672
p_wrong:  1e-9
Data Source:  BioPlex
FBXW11
Tbio
Novelty:  0.0715377
p_int:  0.998303163
p_ni:  0.001696837
Data Source:  BioPlex
SEPT6
Tbio
Novelty:  0.00885503
p_int:  0.99545824
p_ni:  0.00454176
Data Source:  BioPlex
SEPT9
Tchem
Novelty:  0.00407266
p_int:  0.99202665
p_ni:  0.00797335
Data Source:  BioPlex
SEPT7
Tbio
Novelty:  0.00554708
p_int:  0.990132533
p_ni:  0.009867467
Data Source:  BioPlex
SEPT11
Tbio
Novelty:  0.05272429
p_int:  0.989638965
p_ni:  0.010361035
Data Source:  BioPlex
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.1
56.2
intraocular pressure measurement
1
2
2
52.7
1
1
0
1.1
35
hair color
1
1
0
1.1
8.6
heel bone mineral density
1
1
1
6.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
56.2
intraocular pressure measurement
2
52.7
0
1.1
35
hair color
0
1.1
8.6
heel bone mineral density
1
6.7
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
704910
Mouse
MGI:2153589
140500
Rat
RGD:1310711
313772
Dog
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
VGNC:37497
489597
Horse
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
VGNC:14970
100147589
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
Mouse
Rat
Dog
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
Horse
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
Publication Statistics
PubMed Score 6.08
PubMed score by year
PubTator Score 3.71
PubTator score by year