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Tbio
ARAP1
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1

Protein Summary
Description
Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity). The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334211
  • ENSP00000335506
  • ENSG00000186635
  • ENST00000359373
  • ENSP00000352332
  • ENST00000393605
  • ENSP00000377230
  • ENST00000393609
  • ENSP00000377233
  • ENST00000429686
  • ENSP00000403127

Symbol
  • CENTD2
  • KIAA0782
  • CENTD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
interacting protein
0.98
disease perturbation
0.9
transcription factor
0.84
molecular function
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.78   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.78   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (106)
1 – 10 of 106
GRB2
Tchem
Novelty:  0.00091605
p_int:  0.999999998
p_ni:  2e-9
Score:  0.372
Data Source:  BioPlex,STRINGDB
SH3KBP1
Tbio
Family:  Enzyme
Novelty:  0.01454593
p_int:  0.99999999
p_ni:  3e-9
p_wrong:  7e-9
Score:  0.83
Data Source:  BioPlex,STRINGDB
NCK1
Tbio
Novelty:  0.00352084
p_int:  0.999999928
p_ni:  7.2e-8
Data Source:  BioPlex
NCK2
Tbio
Novelty:  0.02220251
p_int:  0.999999716
p_ni:  2.51e-7
p_wrong:  3.4e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
CAPZA2
Tbio
Novelty:  0.14014918
p_int:  0.999998364
p_ni:  0.000001636
Score:  0.336
Data Source:  BioPlex,STRINGDB
FPR2
Tchem
Family:  GPCR
Novelty:  0.00228744
p_int:  0.98798715
p_ni:  0.011785173
p_wrong:  0.000227677
Score:  0.194
Data Source:  BioPlex,STRINGDB
ARF1
Tchem
Family:  Enzyme
Novelty:  0.00208554
Score:  0.949
Data Source:  STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.939
Data Source:  STRINGDB
RHOG
Tbio
Family:  Enzyme
Novelty:  0.00412327
Score:  0.936
Data Source:  STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.93
Data Source:  STRINGDB
Pathways (10)
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 (R-HSA-8849469)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Non-Receptor Tyrosine Kinases
Reactome
Signaling by PTK6
Name
Explore in Pharos
Explore in Source
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
Rho GTPase cycle
Signal Transduction
Signaling by Non-Receptor Tyrosine Kinases
Signaling by PTK6
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
12
7
4
1.1
98.4
testosterone measurement
7
4
7
94.4
HbA1c measurement
2
3
3
92.5
glucose measurement
2
2
2
88.5
serum alanine aminotransferase measurement
2
2
1
6.9
86.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
98.4
testosterone measurement
7
94.4
HbA1c measurement
3
92.5
glucose measurement
2
88.5
serum alanine aminotransferase measurement
1
6.9
86.4
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
VGNC:1610
451406
Macaque
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
718488
Mouse
MGI:1916960
69710
Rat
RGD:1310385
361617
Dog
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
VGNC:38025
485207
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Macaque
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Mouse
Rat
Dog
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Publication Statistics
PubMed Score 24.78
PubMed score by year
PubTator Score 8.71
PubTator score by year