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Tdark
AGAP3
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

Protein Summary
Description
GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. This gene encodes an essential component of the N-methyl-D-aspartate (NMDA) receptor signaling complex which mediates long-term potentiation in synapses by linking activation of NMDA receptor to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking. The encoded protein contains an N-terminal GTPase-like domain, a pleckstrin homology domain, an ArfGAP domain and several C-terminal ankryn repeat domains. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397238
  • ENSP00000380413
  • ENSG00000133612
  • ENST00000463381
  • ENSP00000418016
  • ENST00000473312
  • ENSP00000418921
  • ENST00000622464
  • ENSP00000480655

Symbol
  • CENTG3
  • CRAG
  • AGAP-3
  • CENTG3
  • MRIP-1
  • cnt-g3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.97
transcription factor binding site profile
0.82
transcription factor
0.69
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.84   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.84   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence Orthology (ISO)
UniProtKB
Inferred from Sequence Orthology (ISO)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (14)
1 – 10 of 14
FKBP6
Tbio
Family: Enzyme
Novelty: 0.02749334
p_int: 0.999989061
p_ni: 0.000010939
Score: 0.213
Data Source: BioPlex,STRINGDB
FLCN
Tbio
Novelty: 0.00262361
p_int: 0.999979025
p_ni: 0.000020975
Score: 0.188
Data Source: BioPlex,STRINGDB
GPR156
Tdark
Family: GPCR
Novelty: 0.46666667
p_int: 0.999975733
p_ni: 0.000024267
p_wrong: 1e-9
Data Source: BioPlex
ARHGAP22
Tbio
Family: Enzyme
Novelty: 0.20584913
p_int: 0.999961741
p_ni: 0.000038259
Data Source: BioPlex
LZTS2
Tbio
Novelty: 0.12012012
p_int: 0.999934365
p_ni: 0.000065635
Score: 0.181
Data Source: BioPlex,STRINGDB
KBTBD7
Tdark
Novelty: 1.01449275
p_int: 0.99967918
p_ni: 0.000320722
p_wrong: 9.8e-8
Data Source: BioPlex
JPH4
Tbio
Novelty: 0.02095843
p_int: 0.997330929
p_ni: 0.002650467
p_wrong: 0.000018604
Score: 0.159
Data Source: BioPlex,STRINGDB
MIER2
Tbio
Novelty: 1.42857143
p_int: 0.996707916
p_ni: 0.003292084
Score: 0.214
Data Source: BioPlex,STRINGDB
FGF12
Tbio
Novelty: 0.03928258
p_int: 0.985402499
p_ni: 0.014396384
p_wrong: 0.000201117
Data Source: BioPlex
SYNGAP1
Tbio
Family: Enzyme
Novelty: 0.00957978
Score: 0.614
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.84

PubMed score by year
PubTator Score  34.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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