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Tbio
COL21A1
Collagen alpha-1(XXI) chain

Protein Classes
Protein Summary
Description
This gene encodes the alpha chain of type XXI collagen, a member of the FACIT (fibril-associated collagens with interrupted helices) collagen family. Type XXI collagen is localized to tissues containing type I collagen and maintains the integrity of the extracellular matrix. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244728
  • ENSP00000244728
  • ENSG00000124749
  • ENST00000370819
  • ENSP00000359855

Symbol
  • COL1AL
  • FP633
  • COLA1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.79
tissue sample
0.59
protein domain
0.58
histone modification site profile
0.54
cellular component
0.52


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.12   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.12   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
3
4
93.1
peak expiratory flow
1
1
1
58.4
forced expiratory volume
1
1
1
56
pulse pressure measurement
2
2
2
42.2
FEV/FEC ratio
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
93.1
peak expiratory flow
1
58.4
forced expiratory volume
1
56
pulse pressure measurement
2
42.2
FEV/FEC ratio
1
30.2
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
collagen type XXI alpha 1 chain
VGNC:10696
462788
Macaque
collagen type XXI alpha 1 chain
712070
Dog
collagen type XXI alpha 1 chain
VGNC:39467
474945
Horse
collagen type XXI alpha 1 chain
VGNC:16732
100056839
Opossum
collagen type XXI alpha 1 chain
100018467
Species
Name
OMA
EggNOG
Inparanoid
Chimp
collagen type XXI alpha 1 chain
Macaque
collagen type XXI alpha 1 chain
Dog
collagen type XXI alpha 1 chain
Horse
collagen type XXI alpha 1 chain
Opossum
collagen type XXI alpha 1 chain
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96P44-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen chain trimerization
Reactome
Collagen formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Collagen biosynthesis and modifying enzymes
Collagen chain trimerization
Collagen formation
Extracellular matrix organization
Protein-Protein Interactions (81)
1 – 10 of 81
COL5A2
Tbio
Novelty:  0.01352973
Score:  0.93
Data Source:  STRINGDB
COL19A1
Tbio
Novelty:  0.15030115
Score:  0.929
Data Source:  STRINGDB
COL12A1
Tbio
Novelty:  0.0239421
Score:  0.927
Data Source:  STRINGDB
COL1A2
Tbio
Novelty:  0.00048334
Score:  0.926
Data Source:  STRINGDB
COL11A2
Tbio
Novelty:  0.00923441
Score:  0.924
Data Source:  STRINGDB
COL11A1
Tbio
Novelty:  0.00594683
Score:  0.924
Data Source:  STRINGDB
COL5A1
Tbio
Novelty:  0.00506815
Score:  0.924
Data Source:  STRINGDB
COL1A1
Tbio
Novelty:  0.00063584
Score:  0.923
Data Source:  STRINGDB
COL4A1
Tbio
Novelty:  0.00358049
Score:  0.922
Data Source:  STRINGDB
COL3A1
Tbio
Novelty:  0.00197327
Score:  0.921
Data Source:  STRINGDB
Publication Statistics
PubMed Score  5.12

PubMed score by year
PubTator Score  5.38

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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