COL21A1
Collagen alpha-1(XXI) chain
Protein Classes
Protein Summary
This gene encodes the alpha chain of type XXI collagen, a member of the FACIT (fibril-associated collagens with interrupted helices) collagen family. Type XXI collagen is localized to tissues containing type I collagen and maintains the integrity of the extracellular matrix. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
- ENST00000244728
- ENSP00000244728
- ENSG00000124749
- ENST00000370819
- ENSP00000359855
- COL1AL
- FP633
- COLA1L
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.79 | ||
tissue sample | 0.59 | ||
protein domain | 0.58 | ||
histone modification site profile | 0.54 | ||
cellular component | 0.52 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.12 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 107 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.12 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 107 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (7)
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 3 | 4 | 93.1 | |||||
peak expiratory flow | 1 | 1 | 1 | 58.4 | |||||
forced expiratory volume | 1 | 1 | 1 | 56 | |||||
pulse pressure measurement | 2 | 2 | 2 | 42.2 | |||||
FEV/FEC ratio | 1 | 1 | 1 | 30.2 | |||||
Items per page:
1 – 5 of 7
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 4 | 93.1 | |||||
peak expiratory flow | 1 | 58.4 | |||||
forced expiratory volume | 1 | 56 | |||||
pulse pressure measurement | 2 | 42.2 | |||||
FEV/FEC ratio | 1 | 30.2 | |||||
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | collagen type XXI alpha 1 chain | VGNC:10696 | 462788 | |||||
Macaque | collagen type XXI alpha 1 chain | 712070 | ||||||
Dog | collagen type XXI alpha 1 chain | VGNC:39467 | 474945 | |||||
Horse | collagen type XXI alpha 1 chain | VGNC:16732 | 100056839 | |||||
Opossum | collagen type XXI alpha 1 chain | 100018467 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | collagen type XXI alpha 1 chain | |||||
Macaque | collagen type XXI alpha 1 chain | |||||
Dog | collagen type XXI alpha 1 chain | |||||
Horse | collagen type XXI alpha 1 chain | |||||
Opossum | collagen type XXI alpha 1 chain | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (9)
Reactome (4)
KEGG (1)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Collagen biosynthesis and modifying enzymes | ||||
Reactome | Collagen chain trimerization | ||||
Reactome | Collagen formation | ||||
Reactome | Extracellular matrix organization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Collagen biosynthesis and modifying enzymes | ||||
Collagen chain trimerization | ||||
Collagen formation | ||||
Extracellular matrix organization | ||||
Gene Ontology Terms (9)
Functions (1)
Components (7)
Processes (1)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Protein-Protein Interactions (81)
1 – 10 of 81
COL5A2
Novelty: 0.01352973
Score: 0.93
Data Source: STRINGDB
COL19A1
Novelty: 0.15030115
Score: 0.929
Data Source: STRINGDB
COL12A1
Novelty: 0.0239421
Score: 0.927
Data Source: STRINGDB
COL1A2
Novelty: 0.00048334
Score: 0.926
Data Source: STRINGDB
COL11A2
Novelty: 0.00923441
Score: 0.924
Data Source: STRINGDB
COL11A1
Novelty: 0.00594683
Score: 0.924
Data Source: STRINGDB
COL5A1
Novelty: 0.00506815
Score: 0.924
Data Source: STRINGDB
COL1A1
Novelty: 0.00063584
Score: 0.923
Data Source: STRINGDB
COL4A1
Novelty: 0.00358049
Score: 0.922
Data Source: STRINGDB
COL3A1
Novelty: 0.00197327
Score: 0.921
Data Source: STRINGDB
Publication Statistics
PubMed Score 5.12
PubMed score by year
PubTator Score 5.38
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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