Tbio COL21A1 Collagen alpha-1(XXI) chain

Protein Summary

Description

This gene encodes the alpha chain of type XXI collagen, a member of the FACIT (fibril-associated collagens with interrupted helices) collagen family. Type XXI collagen is localized to tissues containing type I collagen and maintains the integrity of the extracellular matrix. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• Q96P44
• A6NIX5
• B2R8J9
• Q49A51
• Q71RF4
• Q8WXV8
• Q9H0V3

Gene Name

• COL21A1

Ensembl ID

• ENST00000244728
• ENSP00000244728
• ENSG00000124749
• ENST00000370819
• ENSP00000359855

Symbol

• COL1AL
• FP633
• COLA1L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.79
tissue sample	0.59
protein domain	0.58
histone modification site profile	0.54
cellular component	0.52

Protein Classes

PANTHER Classes

Protein / Receptor / Collagen Alpha-1(xxi) Chain

DTO Classes

Protein / Receptor / Collagen Alpha-1(xxi) Chain

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.06   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.06   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0