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Tbio
NT5C1B
Cytosolic 5'-nucleotidase 1B

Protein Summary
Description
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity). This locus represents naturally occurring read-through transcription between the neighboring NT5C1B (5'-nucleotidase, cytosolic IB) and RDH14 (retinol dehydrogenase 14) genes on chromosome 2. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304081
  • ENSP00000305979
  • ENSG00000185013
  • ENST00000359846
  • ENSP00000352904

Symbol
  • AIRP
  • AIRP
  • cN1B
  • cN-IB
  • NT5C1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
cell type or tissue
0.74
virus perturbation
0.59
tissue
0.49
cell line
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.66   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.66   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (126)
NT5C3B
Tbio
Family:  Enzyme
Novelty:  0.20743662
Score:  0.945
Data Source:  STRINGDB
ADSL
Tbio
Family:  Enzyme
Novelty:  0.0028496
Score:  0.936
Data Source:  STRINGDB
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
Score:  0.935
Data Source:  STRINGDB
NT5C
Tbio
Family:  Enzyme
Novelty:  0.00686933
Score:  0.934
Data Source:  STRINGDB
ATIC
Tchem
Novelty:  0.00466845
Score:  0.933
Data Source:  STRINGDB
CMPK2
Tbio
Family:  Kinase
Novelty:  0.01285082
Score:  0.933
Data Source:  STRINGDB
NT5C2
Tbio
Family:  Enzyme
Novelty:  0.00758288
Score:  0.931
Data Source:  STRINGDB
NT5M
Tchem
Family:  Enzyme
Novelty:  0.03299091
Score:  0.928
Data Source:  STRINGDB
DCK
Tchem
Family:  Kinase
Novelty:  0.00201831
Score:  0.925
Data Source:  STRINGDB
NT5C3A
Tbio
Family:  Enzyme
Novelty:  0.01939545
Score:  0.921
Data Source:  STRINGDB
Nearest Tclin Targets (32)
Explore Nearest Tclin Targets
1 – 5 of 26
TYMS
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE1A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE7A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE4A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (11)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase catabolism
Reactome
Purine catabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase catabolism
Purine catabolism
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
5
6
5
6.1
89
2
2
2
38.7
urate measurement
2
2
2
34.8
vital capacity
1
1
1
15.7
forced expiratory volume
1
1
1
15.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
5
6.1
89
2
38.7
urate measurement
2
34.8
vital capacity
1
15.7
forced expiratory volume
1
15.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
5'-nucleotidase, cytosolic IB
470316
Mouse
MGI:1918131
70881
Rat
RGD:1309705
298881
Dog
5'-nucleotidase, cytosolic IB
100856179
Horse
cytosolic 5'-nucleotidase 1B
100056590
Species
Name
OMA
EggNOG
Inparanoid
Chimp
5'-nucleotidase, cytosolic IB
Mouse
Rat
Dog
5'-nucleotidase, cytosolic IB
Horse
cytosolic 5'-nucleotidase 1B
Publication Statistics
PubMed Score 8.66
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title