NLRP3
NACHT, LRR and PYD domains-containing protein 3
Protein Summary
As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu (PubMed:28847925). Activation of NLRP3 inflammasome is also required for HMGB1 secretion (PubMed:22801494). The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. Under resting conditions, NLRP3 is autoinhibited. NLRP3 activation stimuli include extracellular ATP, reactive oxygen species, K(+) efflux, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, cytosolic dsRNA, etc. ...more
- ENST00000336119
- ENSP00000337383
- ENSG00000162711
- ENST00000348069
- ENSP00000294752
- ENST00000366496
- ENSP00000355452
- ENST00000366497
- ENSP00000355453
- ENST00000391827
- ENSP00000375703
- ENST00000391828
- ENSP00000375704
- ENST00000474792
- ENSP00000493937
- ENST00000643234
- ENSP00000493674
- C1orf7
- CIAS1
- NALP3
- PYPAF1
- AII
- AVP
- FCU
- MWS
- FCAS
- KEFH
- CIAS1
- FCAS1
- NALP3
- C1orf7
- CLR1.1
- DFNA34
- PYPAF1
- AGTAVPRL
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
biological process | 0.99 | ||
protein domain | 0.85 | ||
molecular function | 0.81 | ||
phenotype | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2980.85 (req: < 5)
Gene RIFs: 531 (req: <= 3)
Antibodies: 731 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2980.85 (req: >= 5)
Gene RIFs: 531 (req: > 3)
Antibodies: 731 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 39
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 37
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (37)
Protein-Protein Interactions (247)
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
IL1B
Family: Other
KEGG Distance: 2
Common Pathways: 6
2: Pertussis
3: Necroptosis
more: 2 more common pathways
Pathways (17)
Reactome (9)
KEGG (6)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Deubiquitination | ||||
Reactome | Immune System | ||||
Reactome | Inflammasomes | ||||
Reactome | Innate Immune System | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Deubiquitination | ||||
Immune System | ||||
Inflammasomes | ||||
Innate Immune System | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (45)
Functions (5)
Components (6)
Processes (34)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | HGNC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (24)
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 6 | 14 | 16 | 99.2 | |||||
platelet count | 3 | 4 | 4 | 3.1 | 97.2 | ||||
leukocyte count | 2 | 3 | 3 | 92.9 | |||||
neutrophil count | 3 | 3 | 4 | 92.8 | |||||
myeloid white cell count | 2 | 2 | 2 | 92.5 | |||||
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 16 | 99.2 | |||||
platelet count | 4 | 3.1 | 97.2 | ||||
leukocyte count | 3 | 92.9 | |||||
neutrophil count | 4 | 92.8 | |||||
myeloid white cell count | 2 | 92.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | NLR family pyrin domain containing 3 | VGNC:11565 | 469743 | |||||
Macaque | NLR family pyrin domain containing 3 | 701278 | ||||||
Mouse | MGI:2653833 | 216799 | ||||||
Rat | RGD:1308314 | 287362 | ||||||
Dog | NLR family pyrin domain containing 3 | VGNC:43848 | 490576 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | NLR family pyrin domain containing 3 | |||||
Macaque | NLR family pyrin domain containing 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | NLR family pyrin domain containing 3 | |||||
Publication Statistics
PubMed Score 2980.85
PubMed score by year
PubTator Score 1995.33
PubTator score by year
Related Publications
Text Mined References (568)
GeneRif Annotations (531)
Items per page:
0 of 0
PMID | Year | Title |
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