NLRP3
NACHT, LRR and PYD domains-containing protein 3
Protein Summary
As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu (PubMed:28847925). Activation of NLRP3 inflammasome is also required for HMGB1 secretion (PubMed:22801494). The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. Under resting conditions, NLRP3 is autoinhibited. NLRP3 activation stimuli include extracellular ATP, reactive oxygen species, K(+) efflux, crystals of monosodium urate or cholesterol, amyloid-beta fibers, environmental or industrial particles and nanoparticles, cytosolic dsRNA, etc. ...more
- ENST00000336119
- ENSP00000337383
- ENSG00000162711
- ENST00000348069
- ENSP00000294752
- ENST00000366496
- ENSP00000355452
- ENST00000366497
- ENSP00000355453
- ENST00000391827
- ENSP00000375703
- ENST00000391828
- ENSP00000375704
- ENST00000474792
- ENSP00000493937
- ENST00000643234
- ENSP00000493674
- C1orf7
- CIAS1
- NALP3
- PYPAF1
- AII
- AVP
- FCU
- MWS
- FCAS
- KEFH
- CIAS1
- FCAS1
- NALP3
- C1orf7
- CLR1.1
- DFNA34
- PYPAF1
- AGTAVPRL
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
biological process | 0.99 | ||
protein domain | 0.85 | ||
molecular function | 0.81 | ||
phenotype | 0.72 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2624.76 (req: < 5)
Gene RIFs: 531 (req: <= 3)
Antibodies: 731 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2624.76 (req: >= 5)
Gene RIFs: 531 (req: > 3)
Antibodies: 731 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 39
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (5)
1 – 5 of 5
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 4 | 3 | 5 | 99.3 | |||||
fibrinogen measurement | 5 | 3 | 5 | 96.4 | |||||
myeloid white cell count | 2 | 2 | 2 | 88.9 | |||||
neutrophil count | 3 | 2 | 3 | 88.7 | |||||
leukocyte count | 2 | 3 | 3 | 70.6 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 5 | 99.3 | |||||
fibrinogen measurement | 5 | 96.4 | |||||
myeloid white cell count | 2 | 88.9 | |||||
neutrophil count | 3 | 88.7 | |||||
leukocyte count | 3 | 70.6 | |||||
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | NLR family pyrin domain containing 3 | VGNC:11565 | 469743 | |||||
Macaque | NLR family pyrin domain containing 3 | 701278 | ||||||
Mouse | MGI:2653833 | 216799 | ||||||
Rat | RGD:1308314 | 287362 | ||||||
Dog | NLR family pyrin domain containing 3 | VGNC:43848 | 490576 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | NLR family pyrin domain containing 3 | |||||
Macaque | NLR family pyrin domain containing 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | NLR family pyrin domain containing 3 | |||||
Protein Structure (2 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 2 of 2
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (17)
Reactome (9)
KEGG (6)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 9
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Deubiquitination | ||||
Reactome | Immune System | ||||
Reactome | Inflammasomes | ||||
Reactome | Innate Immune System | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Deubiquitination | ||||
Immune System | ||||
Inflammasomes | ||||
Innate Immune System | ||||
Metabolism of proteins | ||||
Gene Ontology Terms (45)
Functions (5)
Components (6)
Processes (34)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | HGNC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (247)
1 – 10 of 247
CASP1
Family: Enzyme
Novelty: 0.00034643
Score: 0.997
Data Source: Reactome,STRINGDB
PYCARD
Novelty: 0.00719985
Score: 0.996
Data Source: Reactome,STRINGDB
IL1B
Novelty: 0.0000308
Score: 0.988
Data Source: STRINGDB
TXNIP
Novelty: 0.00216952
Score: 0.988
Data Source: Reactome,STRINGDB
CARD8
Family: Enzyme
Novelty: 0.0146799
Score: 0.988
Data Source: STRINGDB
AIM2
Novelty: 0.00360474
Score: 0.986
Data Source: STRINGDB
NLRC4
Novelty: 0.0032237
Score: 0.98
Data Source: STRINGDB
DHX33
Family: Enzyme
Novelty: 0.07473852
Score: 0.977
Data Source: STRINGDB
CASP5
Family: Enzyme
Novelty: 0.00734661
Score: 0.976
Data Source: STRINGDB
NEK7
Family: Kinase
Novelty: 0.02675561
Score: 0.967
Data Source: STRINGDB
Publication Statistics
PubMed Score 2624.76
PubMed score by year
PubTator Score 1995.33
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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