NLRP3
NACHT, LRR and PYD domains-containing protein 3
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological term | 1 | ||
biological process | 0.99 | ||
protein domain | 0.85 | ||
molecular function | 0.81 | ||
phenotype | 0.72 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Deubiquitination | ||||
Reactome | Immune System | ||||
Reactome | Inflammasomes | ||||
Reactome | Innate Immune System | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Deubiquitination | ||||
Immune System | ||||
Inflammasomes | ||||
Innate Immune System | ||||
Metabolism of proteins | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | HGNC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
C-reactive protein measurement | 6 | 14 | 16 | 99.2 | |||||
platelet count | 3 | 4 | 4 | 3.1 | 97.2 | ||||
leukocyte count | 2 | 3 | 3 | 92.9 | |||||
neutrophil count | 3 | 3 | 4 | 92.8 | |||||
myeloid white cell count | 2 | 2 | 2 | 92.5 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
C-reactive protein measurement | 16 | 99.2 | |||||
platelet count | 4 | 3.1 | 97.2 | ||||
leukocyte count | 3 | 92.9 | |||||
neutrophil count | 4 | 92.8 | |||||
myeloid white cell count | 2 | 92.5 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | NLR family pyrin domain containing 3 | VGNC:11565 | 469743 | |||||
Macaque | NLR family pyrin domain containing 3 | 701278 | ||||||
Mouse | MGI:2653833 | 216799 | ||||||
Rat | RGD:1308314 | 287362 | ||||||
Dog | NLR family pyrin domain containing 3 | VGNC:43848 | 490576 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | NLR family pyrin domain containing 3 | |||||
Macaque | NLR family pyrin domain containing 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | NLR family pyrin domain containing 3 | |||||
PMID | Year | Title |
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