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Tbio
RPRD1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

Protein Summary
Description
Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. This gene encodes a cell-cycle and transcription regulatory protein. The encoded protein interacts with the cell cycle inhibitor cyclin-dependent kinase 4 inhibitor B and may function as a negative regulator of G(1)/S phase progression. This protein also forms homo- and hetrodimers with the protein, regulation of nuclear pre-mRNA domain-containing protein 1B, to form a scaffold that interacts with the C-terminal domain of RNA polymerase II subunit B1 and regulates several aspects of transcription. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 16. [provided by RefSeq, Dec 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357384
  • ENSP00000349955
  • ENSG00000141425
  • ENST00000399022
  • ENSP00000381984
  • ENST00000588737
  • ENSP00000465444
  • ENST00000590898
  • ENSP00000467991

Symbol
  • P15RS
  • P15RS
  • HsT3101
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
microRNA
0.78
kinase perturbation
0.71
histone modification site profile
0.68
tissue sample
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.29   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.29   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
57.8
1
1
0
1.3
15.8
1
1
0
1.3
15.8
survival time
1
1
0
1.3
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
57.8
0
1.3
15.8
0
1.3
15.8
survival time
0
1.3
15.8
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
regulation of nuclear pre-mRNA domain containing 1A
VGNC:8872
468522
Macaque
regulation of nuclear pre-mRNA domain containing 1A
709217
Mouse
MGI:2385066
225283
Rat
RGD:1307374
291736
Dog
regulation of nuclear pre-mRNA domain containing 1A
VGNC:45726
100856476
Species
Name
OMA
EggNOG
Inparanoid
Chimp
regulation of nuclear pre-mRNA domain containing 1A
Macaque
regulation of nuclear pre-mRNA domain containing 1A
Mouse
Rat
Dog
regulation of nuclear pre-mRNA domain containing 1A
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96P16-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase II Transcription
Reactome
RNA polymerase II transcribes snRNA genes
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase II Transcription
RNA polymerase II transcribes snRNA genes
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Protein-Protein Interactions (146)
1 – 10 of 146
RPRD1B
Tbio
Novelty:  0.0444394
p_int:  1
Score:  0.98
Data Source:  BioPlex,Reactome,STRINGDB
POLR2G
Tbio
Family:  Enzyme
Novelty:  0.01235379
p_int:  0.999971083
p_ni:  0.000028915
p_wrong:  2e-9
Score:  0.981
Data Source:  BioPlex,STRINGDB
LMO2
Tbio
Novelty:  0.0038279
p_int:  0.999969421
p_ni:  0.000030579
Score:  0.515
Data Source:  BioPlex,STRINGDB
POLR2J
Tbio
Family:  Enzyme
Novelty:  0.02344868
p_int:  0.999905892
p_ni:  0.000094108
p_wrong:  1e-9
Score:  0.901
Data Source:  BioPlex,STRINGDB
POLR2M
Tbio
Family:  Enzyme
Novelty:  0.11413088
p_int:  0.999860672
p_ni:  0.000139327
p_wrong:  1e-9
Score:  0.767
Data Source:  BioPlex,STRINGDB
POLR2D
Tdark
Family:  Enzyme
Novelty:  0.11021614
p_int:  0.999026448
p_ni:  0.000973542
p_wrong:  1e-8
Score:  0.98
Data Source:  BioPlex,STRINGDB
ASB6
Tdark
Novelty:  0.32074223
p_int:  0.992818238
p_ni:  0.00717952
p_wrong:  0.000002242
Score:  0.798
Data Source:  BioPlex,STRINGDB
FAM9B
Tdark
Novelty:  0.39508009
p_int:  0.982794697
p_ni:  0.017205303
Data Source:  BioPlex
GPN1
Tbio
Family:  Enzyme
Novelty:  0.06883613
p_int:  0.972686884
p_ni:  0.027221397
p_wrong:  0.000091719
Data Source:  BioPlex
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.963363994
p_ni:  0.036635835
p_wrong:  1.71e-7
Data Source:  BioPlex
Publication Statistics
PubMed Score  8.29

PubMed score by year
PubTator Score  3.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer