Tbio RPRD1A Regulation of nuclear pre-mRNA domain-containing protein 1A

Protein Summary

Description

Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle. This gene encodes a cell-cycle and transcription regulatory protein. The encoded protein interacts with the cell cycle inhibitor cyclin-dependent kinase 4 inhibitor B and may function as a negative regulator of G(1)/S phase progression. This protein also forms homo- and hetrodimers with the protein, regulation of nuclear pre-mRNA domain-containing protein 1B, to form a scaffold that interacts with the C-terminal domain of RNA polymerase II subunit B1 and regulates several aspects of transcription. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 16. [provided by RefSeq, Dec 2014]

Uniprot Accession IDs

• Q96P16
• A8KA42
• B2RBA3
• Q7Z5G8
• Q96FY9
• Q9NVL4

Gene Name

• RPRD1A

Ensembl ID

• ENST00000357384
• ENSP00000349955
• ENSG00000141425
• ENST00000399022
• ENSP00000381984
• ENST00000588737
• ENSP00000465444
• ENST00000590898
• ENSP00000467991

Symbol

• P15RS
• P15RS
• HsT3101

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
microRNA	0.78
kinase perturbation	0.71
histone modification site profile	0.68
tissue sample	0.68

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Inhibitor / Regulation Of Nuclear Pre-mrna Domain-containing Protein 1a

DTO Classes

Protein / Enzyme Modulator / Kinase Modulator / Kinase Inhibitor / Regulation Of Nuclear Pre-mrna Domain-containing Protein 1a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.93   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 104   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.93   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0