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Tchem
BIRC8
Baculoviral IAP repeat-containing protein 8

Protein Summary
Description
Protects against apoptosis mediated by BAX.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000426466
  • ENSP00000412957
  • ENSG00000163098

Symbol
  • ILP2
  • ILP2
  • ILP-2
  • hILP2
  • RNF136
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.84
biological process
0.75
cell line
0.41
cell type or tissue
0.41
tissue sample
0.4


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.91   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.91   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (36)
Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Small cell lung cancer
WikiPathways
Small cell lung cancer
WikiPathways
Small cell lung cancer
WikiPathways
Small cell lung cancer
WikiPathways
Small cell lung cancer
Name
Explore in Pharos
Explore in Source
Small cell lung cancer
Small cell lung cancer
Small cell lung cancer
Small cell lung cancer
Small cell lung cancer
Protein-Protein Interactions (38)
1 – 10 of 38
XIAP
Tchem
Family: Enzyme
Novelty: 0.00068225
p_int: 0.999974832
p_ni: 0.000025168
Score: 0.771
Data Source: BioPlex,STRINGDB
HTRA2
Tbio
Family: Enzyme
Novelty: 0.00078515
p_int: 0.999805316
p_ni: 0.000194684
Score: 0.596
Data Source: BioPlex,STRINGDB
DIABLO
Tbio
Novelty: 0.00107224
p_int: 0.993750372
p_ni: 0.006249628
Score: 0.927
Data Source: BioPlex,STRINGDB
GLUD1
Tbio
Family: Enzyme
Novelty: 0.00439505
p_int: 0.943350768
p_ni: 0.056649232
Score: 0.513
Data Source: BioPlex,STRINGDB
CASP9
Tchem
Family: Enzyme
Novelty: 0.00031573
p_int: 0.916097331
p_wrong: 0.083902669
Score: 0.965
Data Source: BioPlex,STRINGDB
CDK19
Tchem
Family: Kinase
Novelty: 0.03661427
p_int: 0.846760049
p_ni: 0.153239951
Score: 0.161
Data Source: BioPlex,STRINGDB
CASP3
Tchem
Family: Enzyme
Novelty: 0.00004276
Score: 0.928
Data Source: STRINGDB
BIRC7
Tchem
Novelty: 0.00510868
Score: 0.827
Data Source: STRINGDB
APAF1
Tbio
Family: Enzyme
Novelty: 0.00164778
Score: 0.683
Data Source: STRINGDB
BCL2L1
Tchem
Novelty: 0.00021916
Score: 0.633
Data Source: STRINGDB
Publication Statistics
PubMed Score  9.91

PubMed score by year
PubTator Score  6.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer