Tbio WFIKKN1 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1

Protein Summary

Description

Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity). This gene encodes a secreted multidomain protein consisting of a signal peptide, a WAP domain, a follistatin domain, an immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. These domains have been implicated frequently in inhibition of various types of proteases, suggesting that the encoded protein may be a multivalent protease inhibitor and may control the action of multiple types of serine proteases as well as metalloproteinases. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96NZ8
• Q7LDW0
• Q8NBQ1
• Q96S20

Gene Name

• WFIKKN1

Ensembl ID

• ENST00000319070
• ENSP00000324763
• ENSG00000127578

Symbol

• C16orf12
• GASP2
• WFIKKN
• RJD2
• WFIKKN
• WFDC20A
• C16orf12

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
cell type or tissue	0.51
tissue	0.5
molecular function	0.49
cell line	0.46

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.45   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 37   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.45   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 37   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0