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Tbio
FOXN4
Forkhead box protein N4

Protein Summary
Description
Transcription factor essential for neural and some non-neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4-NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development (By similarity). Members of the winged-helix/forkhead family of transcription factors, such as FOXN4, are characterized by a 110-amino acid DNA-binding domain that ca ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299162
  • ENSP00000299162
  • ENSG00000139445
  • ENST00000355216
  • ENSP00000347354
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.67
cell type or tissue
0.6
molecular function
0.6
transcription factor
0.57
PubMedID
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.14   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.14   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
2
3
87.5
alkaline phosphatase measurement
1
1
1
78.5
high density lipoprotein cholesterol measurement
1
1
1
58.4
apolipoprotein A 1 measurement
1
1
1
55.2
apolipoprotein B measurement
1
1
1
52
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
87.5
alkaline phosphatase measurement
1
78.5
high density lipoprotein cholesterol measurement
1
58.4
apolipoprotein A 1 measurement
1
55.2
apolipoprotein B measurement
1
52
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
forkhead box N4
VGNC:5393
467125
Macaque
forkhead box N4 [Source:HGNC Symbol;Acc:HGNC:21399]
Mouse
MGI:2151057
116810
Rat
RGD:1306389
288736
Dog
forkhead box N4
VGNC:40962
486314
Species
Name
OMA
EggNOG
Inparanoid
Chimp
forkhead box N4
Macaque
forkhead box N4 [Source:HGNC Symbol;Acc:HGNC:21399]
Mouse
Rat
Dog
forkhead box N4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96NZ1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (39)
1 – 10 of 39
AMY1A
Tchem
Family:  Enzyme
Novelty:  0.00210045
p_int:  0.971184391
p_ni:  0.028815609
Data Source:  BioPlex
GABARAP
Tbio
Novelty:  0.00444901
p_int:  0.951195845
p_ni:  0.048117972
p_wrong:  0.000686183
Score:  0.379
Data Source:  BioPlex,STRINGDB
NEUROD4
Tbio
Family:  TF
Novelty:  0.03787483
Score:  0.854
Data Source:  STRINGDB
PTF1A
Tbio
Family:  TF
Novelty:  0.00593299
Score:  0.791
Data Source:  STRINGDB
ZNF592
Tbio
Novelty:  0.12109299
Score:  0.78
Data Source:  STRINGDB
ASCL1
Tbio
Family:  TF
Novelty:  0.00274239
Score:  0.747
Data Source:  STRINGDB
BARHL2
Tbio
Family:  TF
Novelty:  0.09447868
Score:  0.735
Data Source:  STRINGDB
NEUROD1
Tbio
Family:  TF
Novelty:  0.00188624
Score:  0.728
Data Source:  STRINGDB
DLL4
Tbio
Novelty:  0.00263355
Score:  0.715
Data Source:  STRINGDB
PROX1
Tbio
Family:  TF
Novelty:  0.00349114
Score:  0.711
Data Source:  STRINGDB
Publication Statistics
PubMed Score  25.14

PubMed score by year
PubTator Score  7.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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