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Tbio
MUS81
Crossover junction endonuclease MUS81

Protein Summary
Description
Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308110
  • ENSP00000307853
  • ENSG00000172732

Symbol
  • SLX3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.9
kinase perturbation
0.88
protein domain
0.85
cell type or tissue
0.75
disease perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.24   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 206.24   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
1
1
65
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
65
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MUS81 structure-specific endonuclease subunit
VGNC:3101
466667
Macaque
MUS81 structure-specific endonuclease subunit
715558
Mouse
MGI:1918961
71711
Rat
RGD:1311957
293678
Dog
MUS81 structure-specific endonuclease subunit
VGNC:43503
476021
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MUS81 structure-specific endonuclease subunit
Macaque
MUS81 structure-specific endonuclease subunit
Mouse
Rat
Dog
MUS81 structure-specific endonuclease subunit
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96NY9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
DNA Double-Strand Break Repair (R-HSA-5693532)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Fanconi Anemia Pathway
Reactome
HDR through Homologous Recombination (HRR)
Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Name
Explore in Pharos
Explore in Source
DNA Double-Strand Break Repair
DNA Repair
Fanconi Anemia Pathway
HDR through Homologous Recombination (HRR)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Protein-Protein Interactions (217)
1 – 10 of 217
FAM9B
Tdark
Novelty: 0.39508009
p_int: 0.999990486
p_ni: 0.000009513
p_wrong: 1e-9
Data Source: BioPlex
EME1
Tbio
Family: Enzyme
Novelty: 0.017415
p_int: 0.999932063
p_ni: 0.000067937
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
ERCC4
Tbio
Family: Enzyme
Novelty: 0.01076913
p_int: 0.999819341
p_ni: 0.000180659
Score: 0.998
Data Source: BioPlex,STRINGDB
CALML3
Tbio
Novelty: 0.0336689
p_int: 0.999698627
p_ni: 0.000295284
p_wrong: 0.000006089
Data Source: BioPlex
SLX4
Tbio
Family: Enzyme
Novelty: 0.01677273
p_int: 0.99812789
p_ni: 0.001797017
p_wrong: 0.000075093
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
ERCC1
Tbio
Novelty: 0.00079472
p_int: 0.985591388
p_ni: 0.000735723
p_wrong: 0.013672889
Score: 0.999
Data Source: BioPlex,STRINGDB
DIS3
Tbio
Family: Enzyme
Novelty: 0.00961238
p_int: 0.978876506
p_ni: 0.021123494
Score: 0.205
Data Source: BioPlex,STRINGDB
EME2
Tbio
Family: Enzyme
Novelty: 0.0613624
Score: 0.999
Data Source: Reactome,STRINGDB
RAD51
Tchem
Novelty: 0.00011516
Score: 0.996
Data Source: STRINGDB
FANCM
Tbio
Novelty: 0.01122278
Score: 0.996
Data Source: STRINGDB
Publication Statistics
PubMed Score  206.24

PubMed score by year
PubTator Score  83.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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