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Tbio
CLIC6
Chloride intracellular channel protein 6

Protein Summary
Description
May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity). This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349499
  • ENSP00000290332
  • ENSG00000159212
  • ENST00000360731
  • ENSP00000353959

Symbol
  • CLIC1L
  • CLIC1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
molecular function
0.93
transcription factor perturbation
0.8
protein domain
0.73
PubMedID
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.74   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.74   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.1
70
2
2
0
1.2
38.8
1
1
0
3.7
1.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
70
0
1.2
38.8
0
3.7
1.8
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chloride intracellular channel 6
VGNC:14654
474099
Macaque
chloride intracellular channel 6
696993
Mouse
MGI:2146607
209195
Rat
RGD:727938
304081
Cow
chloride intracellular channel 6
507243
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chloride intracellular channel 6
Macaque
chloride intracellular channel 6
Mouse
Rat
Cow
chloride intracellular channel 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96NY7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (78)
1 – 10 of 78
CLIC4
Tbio
Family:  IC
Novelty:  0.01088335
p_int:  0.970997195
p_ni:  2.8e-8
p_wrong:  0.029002777
Score:  0.853
Data Source:  BioPlex,STRINGDB
GABRP
Tclin
Family:  IC
Novelty:  0.06210863
Score:  0.713
Data Source:  STRINGDB
TPRN
Tbio
Novelty:  0.05784581
Score:  0.66
Data Source:  STRINGDB
BEST2
Tbio
Family:  IC
Novelty:  0.03182837
Score:  0.651
Data Source:  STRINGDB
BEST1
Tbio
Family:  IC
Novelty:  0.0026324
Score:  0.639
Data Source:  STRINGDB
NIPAL3
Tdark
Novelty:  1.13554467
Score:  0.634
Data Source:  STRINGDB
BEST4
Tbio
Family:  IC
Novelty:  0.06102944
Score:  0.631
Data Source:  STRINGDB
CFTR
Tclin
Family:  IC
Novelty:  0.00012639
Score:  0.621
Data Source:  STRINGDB
BEST3
Tbio
Family:  IC
Novelty:  0.03481733
Score:  0.619
Data Source:  STRINGDB
ANO1
Tclin
Family:  IC
Novelty:  0.00143722
Score:  0.613
Data Source:  STRINGDB
Publication Statistics
PubMed Score  23.74

PubMed score by year
PubTator Score  7.59

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer