Tbio CLIC6 Chloride intracellular channel protein 6

Protein Summary

Description

May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity). This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• Q96NY7
• A8K0U8
• Q8IX31

Gene Name

• CLIC6

Ensembl ID

• ENST00000349499
• ENSP00000290332
• ENSG00000159212
• ENST00000360731
• ENSP00000353959

Symbol

• CLIC1L
• CLIC1L

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.98
molecular function	0.93
transcription factor perturbation	0.8
protein domain	0.73
PubMedID	0.72

Protein Classes

DTO Classes

Protein / Ion Channel / Intracellular Chloride Channel (Clic) Family / Chloride Intracellular Channel Protein 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.35   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 184   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.35   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0