Tbio LRRC7 Leucine-rich repeat-containing protein 7

Protein Summary

Description

Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression.

Uniprot Accession IDs

• Q96NW7
• Q5VXC2
• Q5VXC3
• Q68D07
• Q86VE8
• Q8WX20
• Q9P2I2

Gene Name

• LRRC7

Ensembl ID

• ENST00000035383
• ENSP00000035383
• ENSG00000033122

Symbol

• KIAA1365
• LAP1
• DENSIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.76
cell type or tissue	0.72
cell line	0.61
trait	0.61
phenotype	0.6

Protein Classes

DTO Classes

Leucine-rich Repeat-containing Protein 73

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.09   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 56   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.09   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0