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Tbio
LRRC7
Leucine-rich repeat-containing protein 7

Protein Summary
Description
Required for normal synaptic spine architecture and function. Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term depression.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000035383
  • ENSP00000035383
  • ENSG00000033122

Symbol
  • KIAA1365
  • LAP1
  • DENSIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.76
cell type or tissue
0.72
cell line
0.61
trait
0.61
phenotype
0.6


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.09   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.09   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (132)
JUP
Tbio
Novelty:  0.0081803
Score:  0.917
Data Source:  STRINGDB
OLFM4
Tbio
Novelty:  0.01048505
Score:  0.915
Data Source:  STRINGDB
FRK
Tchem
Family:  Kinase
Novelty:  0.00715757
Score:  0.914
Data Source:  STRINGDB
SPTAN1
Tbio
Novelty:  0.00286901
Score:  0.909
Data Source:  STRINGDB
VCL
Tbio
Novelty:  0.00043107
Score:  0.908
Data Source:  STRINGDB
AOC1
Tchem
Family:  Enzyme
Novelty:  0.00146464
Score:  0.908
Data Source:  STRINGDB
NFKB1
Tclin
Family:  TF
Novelty:  0.00198195
Score:  0.907
Data Source:  STRINGDB
ELANE
Tclin
Family:  Enzyme
Novelty:  0.00026112
Score:  0.906
Data Source:  STRINGDB
HP
Tbio
Novelty:  0.00016649
Score:  0.906
Data Source:  STRINGDB
ARG1
Tchem
Family:  Enzyme
Novelty:  0.00063728
Score:  0.906
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (22)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Assembly and cell surface presentation of NMDA receptors
Reactome
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Assembly and cell surface presentation of NMDA receptors
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Cytokine Signaling in Immune system
FLT3 Signaling
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
4
4
69
1
1
0
5.9
46.7
self reported educational attainment
1
2
2
42.8
mathematical ability
1
2
2
37.4
biological sex
1
1
1
31.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
4
69
0
5.9
46.7
self reported educational attainment
2
42.8
mathematical ability
2
37.4
biological sex
1
31.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2676665
242274
Dog
leucine rich repeat containing 7
VGNC:54044
490218
Horse
leucine rich repeat containing 7
100068467
Cow
leucine rich repeat containing 7
538844
Opossum
leucine rich repeat containing 7
100029825
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
leucine rich repeat containing 7
Horse
leucine rich repeat containing 7
Cow
leucine rich repeat containing 7
Opossum
leucine rich repeat containing 7
Publication Statistics
PubMed Score 34.09
PubMed score by year
PubTator Score 15.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title