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Tchem
SLC46A1
Proton-coupled folate transporter

Protein Summary
Description
Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme. This gene encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a heme transporter in duodenal enterocytes, and potentially in other tissues like liver and kidney. Its localization to the apical membrane or cytoplasm of intestinal cells is modulated by dietary iron levels. Mutations in this gene are associ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000612814
  • ENSP00000480703
  • ENSG00000076351
  • ENST00000618626
  • ENSP00000483652

Symbol
  • HCP1
  • PCFT
  • G21
  • HCP1
  • PCFT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
molecular function
0.73
histone modification site profile
0.72
tissue sample
0.65
biological term
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.44   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.44   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 28
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (28)
CHEMBL4445651
Rendered image for CHEMBL4445651
CHEMBL1834488
Rendered image for CHEMBL1834488
CHEMBL3628344
Rendered image for CHEMBL3628344
CHEMBL4465095
Rendered image for CHEMBL4465095
CHEMBL3628346
Rendered image for CHEMBL3628346
CHEMBL4557278
Rendered image for CHEMBL4557278
CHEMBL4553188
Rendered image for CHEMBL4553188
CHEMBL4538151
Rendered image for CHEMBL4538151
CHEMBL4214638
Rendered image for CHEMBL4214638
CHEMBL4447805
Rendered image for CHEMBL4447805
Protein-Protein Interactions (77)
SLC22A9
Tbio
Family:  Transporter
Novelty:  0.02212992
p_int:  0.766762851
p_ni:  0.232731203
p_wrong:  0.000505946
Score:  0.344
Data Source:  BioPlex,STRINGDB
SLC19A1
Tchem
Family:  Transporter
Novelty:  0.00536763
Score:  0.794
Data Source:  STRINGDB
FLVCR1
Tbio
Novelty:  0.02110276
Score:  0.772
Data Source:  STRINGDB
QDPR
Tchem
Family:  Enzyme
Novelty:  0.00836889
Score:  0.76
Data Source:  STRINGDB
FOLR1
Tchem
Novelty:  0.00283538
Score:  0.744
Data Source:  STRINGDB
FLVCR2
Tbio
Novelty:  0.02871146
Score:  0.72
Data Source:  STRINGDB
SLC11A2
Tchem
Family:  Transporter
Novelty:  0.00189409
Score:  0.698
Data Source:  STRINGDB
FOLR2
Tchem
Novelty:  0.00751372
Score:  0.684
Data Source:  STRINGDB
CYBRD1
Tbio
Family:  Enzyme
Novelty:  0.01128708
Score:  0.678
Data Source:  STRINGDB
FPGS
Tchem
Family:  Enzyme
Novelty:  0.0108601
Score:  0.669
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (156)
Iron uptake and transport (R-HSA-917937)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Iron uptake and transport
Reactome
Metabolism
Reactome
Metabolism of folate and pterines
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Name
Explore in Pharos
Explore in Source
Iron uptake and transport
Metabolism
Metabolism of folate and pterines
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred by Curator (IC)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
8
4
9
92.8
osteoprotegerin measurement
2
1
2
86.6
interleukin-27 measurement
1
1
1
84.6
apolipoprotein B measurement
2
3
3
83
apolipoprotein A 1 measurement
2
2
2
81.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
9
92.8
osteoprotegerin measurement
2
86.6
interleukin-27 measurement
1
84.6
apolipoprotein B measurement
3
83
apolipoprotein A 1 measurement
2
81.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 46 member 1
708727
Mouse
MGI:1098733
52466
Rat
RGD:1309472
303333
Dog
solute carrier family 46 member 1
VGNC:46426
491166
Horse
solute carrier family 46 member 1
VGNC:23227
100072047
Species
Name
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 46 member 1
Mouse
Rat
Dog
solute carrier family 46 member 1
Horse
solute carrier family 46 member 1
Publication Statistics
PubMed Score 227.44
PubMed score by year
PubTator Score 134.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title