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Tchem
SLC46A1
Proton-coupled folate transporter

Protein Summary
Description
Has been shown to act both as an intestinal proton-coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme. This gene encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a heme transporter in duodenal enterocytes, and potentially in other tissues like liver and kidney. Its localization to the apical membrane or cytoplasm of intestinal cells is modulated by dietary iron levels. Mutations in this gene are associ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000612814
  • ENSP00000480703
  • ENSG00000076351
  • ENST00000618626
  • ENSP00000483652

Symbol
  • HCP1
  • PCFT
  • G21
  • HCP1
  • PCFT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
molecular function
0.73
histone modification site profile
0.72
tissue sample
0.65
biological term
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.44   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.44   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 28
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Protein-Protein Interactions (77)
1 – 10 of 77
SLC22A9
Tbio
Family:  Transporter
Novelty:  0.02212992
p_int:  0.766762851
p_ni:  0.232731203
p_wrong:  0.000505946
Score:  0.344
Data Source:  BioPlex,STRINGDB
SLC19A1
Tchem
Family:  Transporter
Novelty:  0.00536763
Score:  0.794
Data Source:  STRINGDB
FLVCR1
Tbio
Novelty:  0.02110276
Score:  0.772
Data Source:  STRINGDB
QDPR
Tchem
Family:  Enzyme
Novelty:  0.00836889
Score:  0.76
Data Source:  STRINGDB
FOLR1
Tchem
Novelty:  0.00283538
Score:  0.744
Data Source:  STRINGDB
FLVCR2
Tbio
Novelty:  0.02871146
Score:  0.72
Data Source:  STRINGDB
SLC11A2
Tchem
Family:  Transporter
Novelty:  0.00189409
Score:  0.698
Data Source:  STRINGDB
FOLR2
Tchem
Novelty:  0.00751372
Score:  0.684
Data Source:  STRINGDB
CYBRD1
Tbio
Family:  Enzyme
Novelty:  0.01128708
Score:  0.678
Data Source:  STRINGDB
FPGS
Tchem
Family:  Enzyme
Novelty:  0.0108601
Score:  0.669
Data Source:  STRINGDB
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