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Tbio
RDH12
Retinol dehydrogenase 12

Protein Summary
Description
Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. Also involved in the metabolism of short-chain aldehydes. No steroid dehydrogenase activity detected. Might be the key enzyme in the formation of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments. The protein encoded by this gene is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in this gene are a cause of Leber congenital amaurosis type 13 and Retinitis Pigmentosa 53. [provided by RefSeq, Sep 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267502
  • ENSP00000267502
  • ENSG00000139988
  • ENST00000551171
  • ENSP00000449079

Symbol
  • SDR7C2
  • RP53
  • LCA13
  • SDR7C2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.52
gene perturbation
0.5
biological term
0.46
tissue sample
0.46
chemical
0.45


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.23   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.23   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
100615509
Macaque
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
711438
Mouse
MGI:1925224
77974
Rat
RGD:1310462
314264
Dog
retinol dehydrogenase 12
VGNC:52598
490744
Species
Name
OMA
EggNOG
Inparanoid
Chimp
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
Macaque
retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
Mouse
Rat
Dog
retinol dehydrogenase 12
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96NR8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (26)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases associated with visual transduction
Reactome
Diseases of signal transduction
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Disease
Diseases associated with visual transduction
Diseases of signal transduction
G alpha (i) signalling events
GPCR downstream signalling
Protein-Protein Interactions (112)
1 – 10 of 112
TSPAN5
Tbio
Novelty: 0.08879443
p_int: 0.999987899
p_ni: 0.000012099
p_wrong: 2e-9
Data Source: BioPlex
PEX19
Tbio
Novelty: 0.00605342
p_int: 0.999975442
p_ni: 0.000024558
Data Source: BioPlex
TKFC
Tbio
Family: Enzyme
Novelty: 0.00380602
p_int: 0.999859658
p_ni: 0.000086344
p_wrong: 0.000053998
Score: 0.316
Data Source: BioPlex,STRINGDB
LASP1
Tbio
Novelty: 0.00960538
p_int: 0.985216774
p_ni: 0.014783226
Score: 0.184
Data Source: BioPlex,STRINGDB
EIF4EBP2
Tbio
Novelty: 0.01926413
p_int: 0.985200231
p_ni: 0.006038371
p_wrong: 0.008761397
Score: 0.228
Data Source: BioPlex,STRINGDB
NME2P1
Tdark
Family: Kinase
p_int: 0.980409502
p_ni: 0.019590496
p_wrong: 2e-9
Data Source: BioPlex
UBE2E3
Tbio
Novelty: 0.03477232
p_int: 0.974392365
p_ni: 0.022186645
p_wrong: 0.00342099
Data Source: BioPlex
ARPIN
Tbio
Novelty: 0.18393143
p_int: 0.957511357
p_ni: 0.038047283
p_wrong: 0.004441361
Score: 0.199
Data Source: BioPlex,STRINGDB
STAMBP
Tbio
Novelty: 0.01543821
p_int: 0.949521029
p_ni: 0.050123652
p_wrong: 0.000355319
Score: 0.176
Data Source: BioPlex,STRINGDB
RNF123
Tbio
Family: Enzyme
Novelty: 0.01872044
p_int: 0.895502638
p_ni: 0.104497362
Data Source: BioPlex
Publication Statistics
PubMed Score  64.23

PubMed score by year
PubTator Score  36.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer