Tbio AIFM3 Apoptosis-inducing factor 3

Protein Summary

Description

Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential.

Uniprot Accession IDs

• Q96NN9
• B7WP37
• D3DX37
• D3DX38
• Q6ZT44
• Q8N1V3
• Q8N5E0

Gene Name

• AIFM3

Ensembl ID

• ENST00000399163
• ENSP00000382116
• ENSG00000183773
• ENST00000399167
• ENSP00000382120
• ENST00000405089
• ENSP00000385800
• ENST00000440238
• ENSP00000390798

Symbol

• AIFL
• AIFL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
cell type or tissue	0.74
molecular function	0.67
cellular component	0.65
transcription factor	0.65

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Apoptosis-inducing Factor 3

Protein / Oxidoreductase / Oxidase / Apoptosis-inducing Factor 3

Protein / Oxidoreductase / Dehydrogenase / Apoptosis-inducing Factor 3

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Apoptosis-inducing Factor 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.61   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 191   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.61   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0