Tbio SCLT1 Sodium channel and clathrin linker 1

Protein Summary

Description

Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity). This gene encodes an adaptor protein. Studies of a related gene in rat suggest that the encoded protein functions to link clathrin to the sodium channel protein type 10 subunit alpha protein. The encoded protein has also been identified as a component of distal appendages of centrioles that is necessary for ciliogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• Q96NL6
• A4QN04
• Q0VAH2
• Q6P2M4

Gene Name

• SCLT1

Ensembl ID

• ENST00000281142
• ENSP00000281142
• ENSG00000151466
• ENST00000439369
• ENSP00000395292
• ENST00000511426
• ENSP00000420861

Symbol

• SAP1
• CAP1A
• CAP-1A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.79
cellular component	0.74
histone modification site profile	0.74
cell line	0.61
transcription factor binding site profile	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.85   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 133   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.85   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0