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Tbio
SCLT1
Sodium channel and clathrin linker 1

Protein Summary
Description
Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity). This gene encodes an adaptor protein. Studies of a related gene in rat suggest that the encoded protein functions to link clathrin to the sodium channel protein type 10 subunit alpha protein. The encoded protein has also been identified as a component of distal appendages of centrioles that is necessary for ciliogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281142
  • ENSP00000281142
  • ENSG00000151466
  • ENST00000439369
  • ENSP00000395292
  • ENST00000511426
  • ENSP00000420861

Symbol
  • SAP1
  • CAP1A
  • CAP-1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.79
cellular component
0.74
histone modification site profile
0.74
cell line
0.61
transcription factor binding site profile
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.26   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.26   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (135)
KIZ
Tbio
Novelty:  0.0644373
p_int:  0.99999996
p_ni:  1e-9
p_wrong:  4e-8
Score:  0.936
Data Source:  BioPlex,STRINGDB
SYCE3
Tdark
Novelty:  0.22361224
p_int:  0.999999885
p_ni:  1.15e-7
Score:  0.516
Data Source:  BioPlex,STRINGDB
EXOC3
Tbio
Novelty:  0.01051955
p_int:  0.999999066
p_ni:  9.05e-7
p_wrong:  2.9e-8
Score:  0.67
Data Source:  BioPlex,STRINGDB
BORCS6
Tdark
Novelty:  0.83789033
p_int:  0.99999831
p_ni:  0.000001689
Data Source:  BioPlex
BFSP1
Tbio
Novelty:  0.01519136
p_int:  0.999158805
p_ni:  0.000818958
p_wrong:  0.000022237
Data Source:  BioPlex
TPM1
Tbio
Novelty:  0.00261206
p_int:  0.998773183
p_ni:  0.001216397
p_wrong:  0.00001042
Score:  0.213
Data Source:  BioPlex,STRINGDB
CEP83
Tdark
Novelty:  0.15704554
Score:  0.993
Data Source:  STRINGDB
CEP89
Tbio
Novelty:  0.17461805
Score:  0.992
Data Source:  STRINGDB
FBF1
Tbio
Novelty:  0.0409747
Score:  0.985
Data Source:  STRINGDB
CEP164
Tbio
Novelty:  0.04775724
Score:  0.981
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Anchoring of the basal body to the plasma membrane (R-HSA-5620912)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Anchoring of the basal body to the plasma membrane
Cilium Assembly
Organelle biogenesis and maintenance
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
1
3
61.4
risky sexual behaviour measurement
1
1
1
39.6
self reported educational attainment
1
1
1
24.5
1
1
1
2.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
61.4
risky sexual behaviour measurement
1
39.6
self reported educational attainment
1
24.5
1
2.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sodium channel and clathrin linker 1
VGNC:12970
461486
Macaque
sodium channel and clathrin linker 1
693822
Mouse
MGI:1914411
67161
Rat
RGD:628721
266809
Dog
sodium channel and clathrin linker 1
VGNC:54813
483829
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sodium channel and clathrin linker 1
Macaque
sodium channel and clathrin linker 1
Mouse
Rat
Dog
sodium channel and clathrin linker 1
Publication Statistics
PubMed Score 9.26
PubMed score by year
PubTator Score 5.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title