Tdark ZNF830 Zinc finger protein 830

Protein Summary

Description

May play a role in pre-mRNA splicing as component of the spliceosome (PubMed:25599396). Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity. During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation. Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells. During the embryo preimplantation, controls different aspects of M phase. During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription (By similarity).

Uniprot Accession IDs

• Q96NB3
• Q96F60
• Q96GZ5
• Q9BU38

Gene Name

• ZNF830

Ensembl ID

• ENST00000361952
• ENSP00000354518
• ENSG00000198783

Symbol

• CCDC16
• OMCG1
• CCDC16

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.93
tissue	0.68
transcription factor binding site profile	0.67
cell type or tissue	0.65
virus perturbation	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.98   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 100   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.98   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (118)

Explore Interacting Targets

1 – 10 of 118

• See Interactions on String-DB

PPIE

Tbio

Family:  Enzyme

Novelty:  0.01586411

p_int:  0.999999969

p_ni:  1.2e-8

p_wrong:  1.9e-8

Score:  0.983

Data Source:  BioPlex,STRINGDB

PPIL2

Tbio

Family:  Enzyme

Novelty:  0.04860473

p_int:  0.999997176

p_ni:  0.000002823

p_wrong:  1e-9

Score:  0.801

Data Source:  BioPlex,STRINGDB

SNRPE

Tbio

Novelty:  0.02033423

p_int:  0.999883976

p_ni:  0.000116017

p_wrong:  7e-9

Data Source:  BioPlex

SNW1

Tbio

Novelty:  0.01423797

p_int:  0.99985443

p_ni:  0.000143876

p_wrong:  0.000001693

Score:  0.729

Data Source:  BioPlex,STRINGDB

APPL1

Tbio

Novelty:  0.00973424

p_int:  0.998266313

p_ni:  0.001567216

p_wrong:  0.000166471

Score:  0.197

Data Source:  BioPlex,STRINGDB

PRPF19

Tbio

Novelty:  0.01616737

p_int:  0.946679724

p_ni:  0.000256518

p_wrong:  0.053063758

Score:  0.977

Data Source:  BioPlex,STRINGDB

AQR

Tbio

Novelty:  0.00434312

Score:  0.982

Data Source:  STRINGDB

XAB2

Tbio

Novelty:  0.04104647

Score:  0.976

Data Source:  STRINGDB

SF3A1

Tbio

Novelty:  0.03405702

Score:  0.953

Data Source:  STRINGDB

ERCC3

Tbio

Family:  Enzyme

Novelty:  0.00978601

Score:  0.918

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (6)

DNA Repair (R-HSA-73894)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	DNA Repair	306 targets	R-HSA-73894
Reactome	Dual incision in TC-NER	65 targets	R-HSA-6782135
Reactome	Formation of TC-NER Pre-Incision Complex	53 targets	R-HSA-6781823
Reactome	Gap-filling DNA repair synthesis and ligation in TC-NER	64 targets	R-HSA-6782210
Reactome	Nucleotide Excision Repair	110 targets	R-HSA-5696398

Name	Explore in Pharos	Explore in Source
DNA Repair	306 targets	R-HSA-73894
Dual incision in TC-NER	65 targets	R-HSA-6782135
Formation of TC-NER Pre-Incision Complex	53 targets	R-HSA-6781823
Gap-filling DNA repair synthesis and ligation in TC-NER	64 targets	R-HSA-6782210
Nucleotide Excision Repair	110 targets	R-HSA-5696398

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (22)

Functions (2)

Components (5)

Processes (15)

Find Similar Targets

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10

1 – 2 of 2

GO Term	Evidence	Assigned by
nucleic acid binding	Inferred from Electronic Annotation (IEA)	InterPro
zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
QT interval	EFO_0004682	2	1	0	1.2	57.8
macrophage inflammatory protein 1b measurement	EFO_0008219	1	1	1		48.5
pulse pressure measurement	EFO_0005763	1	1	1		45.7
TPE interval measurement	EFO_0004644	1	1	1		21.5
self reported educational attainment	EFO_0004784	1	1	1		7.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
QT interval	EFO_0004682	0	1.2	57.8
macrophage inflammatory protein 1b measurement	EFO_0008219	1		48.5
pulse pressure measurement	EFO_0005763	1		45.7
TPE interval measurement	EFO_0004644	1		21.5
self reported educational attainment	EFO_0004784	1		7.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Acetylation
Cell cycle
Cell division
Chromosome
Coiled coil
Complete proteome
Developmental protein
Metal-binding
Mitosis
mRNA processing

GWAS Trait Find Similar Targets

No Header	No Header
macrophage inflammatory protein 1b measurement
pulse pressure measurement
QT interval
self reported educational attainment
TPE interval measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
embryo phenotype
mortality/aging
reproductive system phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 830	VGNC:9808	454580
Macaque	zinc finger protein 830		715130
Mouse	zinc finger protein 830	MGI:1914233	66983
Rat	zinc finger protein 830	RGD:1562573	497967
Dog	zinc finger protein 830	VGNC:48828	480608

Species	Name	OMA	EggNOG	Inparanoid
Chimp	zinc finger protein 830
Macaque	zinc finger protein 830
Mouse	zinc finger protein 830
Rat	zinc finger protein 830
Dog	zinc finger protein 830

Publication Statistics

PubMed Score 2.98

PubMed score by year

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PubTator Score 0.60

PubTator score by year

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Related Publications

Text Mined References (12)

GeneRif Annotations (1)

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PMID	Year	Title