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Tdark
ZNF830
Zinc finger protein 830

Protein Summary
Description
May play a role in pre-mRNA splicing as component of the spliceosome (PubMed:25599396). Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity. During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation. Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells. During the embryo preimplantation, controls different aspects of M phase. During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361952
  • ENSP00000354518
  • ENSG00000198783

Symbol
  • CCDC16
  • OMCG1
  • CCDC16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.93
tissue
0.68
transcription factor binding site profile
0.67
cell type or tissue
0.65
virus perturbation
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.98   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.98   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (118)
PPIE
Tbio
Family:  Enzyme
Novelty:  0.01586411
p_int:  0.999999969
p_ni:  1.2e-8
p_wrong:  1.9e-8
Score:  0.983
Data Source:  BioPlex,STRINGDB
PPIL2
Tbio
Family:  Enzyme
Novelty:  0.04860473
p_int:  0.999997176
p_ni:  0.000002823
p_wrong:  1e-9
Score:  0.801
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.999883976
p_ni:  0.000116017
p_wrong:  7e-9
Data Source:  BioPlex
SNW1
Tbio
Novelty:  0.01423797
p_int:  0.99985443
p_ni:  0.000143876
p_wrong:  0.000001693
Score:  0.729
Data Source:  BioPlex,STRINGDB
APPL1
Tbio
Novelty:  0.00973424
p_int:  0.998266313
p_ni:  0.001567216
p_wrong:  0.000166471
Score:  0.197
Data Source:  BioPlex,STRINGDB
PRPF19
Tbio
Novelty:  0.01616737
p_int:  0.946679724
p_ni:  0.000256518
p_wrong:  0.053063758
Score:  0.977
Data Source:  BioPlex,STRINGDB
AQR
Tbio
Novelty:  0.00434312
Score:  0.982
Data Source:  STRINGDB
XAB2
Tbio
Novelty:  0.04104647
Score:  0.976
Data Source:  STRINGDB
SF3A1
Tbio
Novelty:  0.03405702
Score:  0.953
Data Source:  STRINGDB
ERCC3
Tbio
Family:  Enzyme
Novelty:  0.00978601
Score:  0.918
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
DNA Repair (R-HSA-73894)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Dual incision in TC-NER
Reactome
Formation of TC-NER Pre-Incision Complex
Reactome
Gap-filling DNA repair synthesis and ligation in TC-NER
Reactome
Nucleotide Excision Repair
Name
Explore in Pharos
Explore in Source
DNA Repair
Dual incision in TC-NER
Formation of TC-NER Pre-Incision Complex
Gap-filling DNA repair synthesis and ligation in TC-NER
Nucleotide Excision Repair
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
2
1
0
1.2
57.8
macrophage inflammatory protein 1b measurement
1
1
1
48.5
pulse pressure measurement
1
1
1
45.7
TPE interval measurement
1
1
1
21.5
self reported educational attainment
1
1
1
7.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
0
1.2
57.8
macrophage inflammatory protein 1b measurement
1
48.5
pulse pressure measurement
1
45.7
TPE interval measurement
1
21.5
self reported educational attainment
1
7.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 830
VGNC:9808
454580
Macaque
zinc finger protein 830
715130
Mouse
MGI:1914233
66983
Rat
RGD:1562573
497967
Dog
zinc finger protein 830
VGNC:48828
480608
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 830
Macaque
zinc finger protein 830
Mouse
Rat
Dog
zinc finger protein 830
Publication Statistics
PubMed Score 2.98
PubMed score by year
PubTator Score 0.60
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title