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Tdark
SFXN2
Sideroflexin-2

Protein Summary
Description
Potential iron transporter.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369893
  • ENSP00000358909
  • ENSG00000156398

Symbol
  • SLC56A2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
transcription factor binding site profile
0.69
tissue sample
0.62
transcription factor perturbation
0.61
disease perturbation
0.56


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.86   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.86   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (50)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
2
1
10.1
92
BMI-adjusted waist circumference
1
6
6
89.5
monocyte count
2
2
2
84.5
5
4
1
1.1
81.7
glomerular filtration rate
4
2
3
6.1
81.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
10.1
92
BMI-adjusted waist circumference
6
89.5
monocyte count
2
84.5
1
1.1
81.7
glomerular filtration rate
3
6.1
81.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sideroflexin 2
VGNC:5724
745798
Mouse
MGI:2137678
94279
Dog
sideroflexin 2
VGNC:46088
100855721
Horse
sideroflexin 2
VGNC:22908
100059866
Cow
sideroflexin 2
VGNC:34531
513450
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sideroflexin 2
Mouse
Dog
sideroflexin 2
Horse
sideroflexin 2
Cow
sideroflexin 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96NB2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (28)
1 – 10 of 28
CDK18
Tchem
Family:  Kinase
Novelty:  0.053383
p_int:  0.999977064
p_ni:  0.000022936
Score:  0.395
Data Source:  BioPlex,STRINGDB
SPG7
Tbio
Family:  Enzyme
Novelty:  0.00463357
Score:  0.876
Data Source:  STRINGDB
TOMM7
Tbio
Novelty:  0.03885154
Score:  0.819
Data Source:  STRINGDB
TOMM70
Tbio
Novelty:  0.00943973
Score:  0.804
Data Source:  STRINGDB
SNRNP200
Tchem
Family:  Enzyme
Novelty:  0.01339666
Score:  0.626
Data Source:  STRINGDB
SVEP1
Tbio
Novelty:  0.05247728
Score:  0.626
Data Source:  STRINGDB
NDUFAF6
Tbio
Family:  Enzyme
Novelty:  0.07584052
Score:  0.55
Data Source:  STRINGDB
HSPA14
Tbio
Novelty:  0.01714625
Score:  0.539
Data Source:  STRINGDB
EIF1B
Tbio
Novelty:  0.10540689
Score:  0.53
Data Source:  STRINGDB
SLC25A1
Tbio
Family:  Transporter
Novelty:  0.00547533
Score:  0.527
Data Source:  STRINGDB
Publication Statistics
PubMed Score  3.86

PubMed score by year
PubTator Score  2.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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