Tbio RILP Rab-interacting lysosomal protein

Protein Summary

Description

Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes. This gene encodes a lysosomal protein that interacts with RAB7, a small GTPase that controls transport to endocytic degradative compartments. Studies using mutant forms of the two proteins suggest that this protein represents a downstream effector for RAB7, and both proteins act together in the regulation of late endocytic traffic. A unique region of this protein has also been shown to be involved in the regulation of lysosomal morphology. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• Q96NA2
• B2RBQ8
• Q71RE6
• Q9BSL3
• Q9BYS3

Gene Name

• RILP

Ensembl ID

• ENST00000301336
• ENSP00000301336
• ENSG00000167705
• ENST00000622136
• ENSP00000481849
• ENSG00000274145

Symbol

• PP10141

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.79
transcription factor binding site profile	0.68
cell type or tissue	0.67
histone modification site profile	0.54
cell line	0.53

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rab-interacting Lysosomal Protein

DTO Classes

Protein / Nucleic Acid Binding / Rab-interacting Lysosomal Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.78   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 64   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.78   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0