You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SPATA13
Spermatogenesis-associated protein 13

Protein Summary
Description
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343003
  • ENSP00000343631
  • ENSG00000182957
  • ENST00000382095
  • ENSP00000371527
  • ENST00000382108
  • ENSP00000371542
  • ENST00000399949
  • ENSP00000382830
  • ENST00000424834
  • ENSP00000398560

Symbol
  • ASEF2
  • ARHGEF29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
trait
0.75
virus perturbation
0.72
tissue sample
0.68
phenotype
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.83   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.83   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
3
94
autoimmune thyroid disease
1
1
0
1.1
72.7
thyroid stimulating hormone measurement
1
1
1
64
Thyroid preparation use measurement
1
1
1
59.3
mean corpuscular volume
1
1
1
22.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
94
autoimmune thyroid disease
0
1.1
72.7
thyroid stimulating hormone measurement
1
64
Thyroid preparation use measurement
1
59.3
mean corpuscular volume
1
22.3
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:104838
219140
Rat
RGD:1307364
305938
Dog
spermatogenesis associated 13
486040
Zebrafish
ZDB-GENE-091116-25
568426
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
spermatogenesis associated 13
Zebrafish
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96N96-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (63)
1 – 10 of 63
YWHAZ
Tbio
Novelty: 0.00210582
p_int: 0.997843189
p_ni: 0.002156811
Score: 0.338
Data Source: BioPlex,STRINGDB
YWHAG
Tbio
Novelty: 0.00845572
p_int: 0.99241739
p_ni: 0.00758261
Score: 0.338
Data Source: BioPlex,STRINGDB
YWHAE
Tbio
Novelty: 0.00431876
p_int: 0.989884086
p_ni: 0.010115914
Score: 0.357
Data Source: BioPlex,STRINGDB
YWHAB
Tchem
Novelty: 0.00614093
p_int: 0.980671201
p_ni: 0.019328799
Score: 0.352
Data Source: BioPlex,STRINGDB
GLDC
Tbio
Family: Enzyme
Novelty: 0.00900467
p_int: 0.957971573
p_ni: 0.042028427
Score: 0.214
Data Source: BioPlex,STRINGDB
YWHAH
Tchem
Novelty: 0.01000071
p_int: 0.93420564
p_ni: 0.06579436
Score: 0.374
Data Source: BioPlex,STRINGDB
YWHAQ
Tchem
Novelty: 0.00234496
p_int: 0.920045606
p_ni: 0.079954394
Score: 0.418
Data Source: BioPlex,STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.979
Data Source: STRINGDB
RAC1
Tbio
Family: Enzyme
Novelty: 0.00365325
Score: 0.971
Data Source: STRINGDB
APC
Tbio
Novelty: 0.00168376
Score: 0.963
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.83

PubMed score by year
PubTator Score  8.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: