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Tbio
SLC6A18
Inactive sodium-dependent neutral amino acid transporter B(0)AT3

Protein Summary
Description
Does not show neutral amino acid transporter activity. The SLC6 family of proteins, which includes SLC6A18, act as specific transporters for neurotransmitters, amino acids, and osmolytes like betaine, taurine, and creatine. SLC6 proteins are sodium cotransporters that derive the energy for solute transport from the electrochemical gradient for sodium ions (Hoglund et al., 2005 [PubMed 16125675]).[supplied by OMIM, Apr 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324642
  • ENSP00000323549
  • ENSG00000164363

Symbol
  • XTRP2
  • Xtrp2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.63
cell line
0.57
virus perturbation
0.5
metabolite
0.45
tissue
0.44


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.71   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 70   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.71   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (33)
1 – 10 of 33
SLC36A2
Tchem
Family:  Transporter
Novelty:  0.01345844
Score:  0.906
Data Source:  STRINGDB
SLC1A7
Tchem
Family:  Transporter
Novelty:  0.00067678
Score:  0.81
Data Source:  STRINGDB
CLPTM1L
Tbio
Novelty:  0.01351819
Score:  0.751
Data Source:  STRINGDB
SLC5A2
Tclin
Family:  Transporter
Novelty:  0.00066797
Score:  0.722
Data Source:  STRINGDB
CLTRN
Tbio
Novelty:  0.02711437
Score:  0.657
Data Source:  STRINGDB
CHEK2
Tchem
Family:  Kinase
Novelty:  0.00068355
Score:  0.64
Data Source:  STRINGDB
TTC16
Tdark
Novelty:  14.55737705
Score:  0.603
Data Source:  STRINGDB
SLC5A1
Tclin
Family:  Transporter
Novelty:  0.00113611
Score:  0.592
Data Source:  STRINGDB
OR12D2
Tdark
Family:  oGPCR
Novelty:  2.69407736
Score:  0.581
Data Source:  STRINGDB
NF1
Tbio
Novelty:  0.00019092
Score:  0.576
Data Source:  STRINGDB
Pathways (25)
Amino acid transport across the plasma membrane (R-HSA-352230)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino acid transport across the plasma membrane
Reactome
Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Na+/Cl- dependent neurotransmitter transporters
Name
Explore in Pharos
Explore in Source
Amino acid transport across the plasma membrane
Defective SLC6A18 may confer susceptibility to iminoglycinuria and/or hyperglycinuria
Disease
Disorders of transmembrane transporters
Na+/Cl- dependent neurotransmitter transporters
GWAS Traits (73)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
6
0
1.3
97.9
6
4
2
1.2
97.2
neutrophil count
5
4
6
97.1
7
3
0
1.3
97
8
3
0
1.5
96.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
97.9
2
1.2
97.2
neutrophil count
6
97.1
0
1.3
97
0
1.5
96.8
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 6 member 18
VGNC:8647
461694
Macaque
solute carrier family 6 member 18
723065
Mouse
MGI:1336892
22598
Rat
RGD:69352
29323
Dog
solute carrier family 6 member 18
VGNC:46460
478631
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 6 member 18
Macaque
solute carrier family 6 member 18
Mouse
Rat
Dog
solute carrier family 6 member 18
Publication Statistics
PubMed Score 7.71
PubMed score by year
PubTator Score 5.44
PubTator score by year