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Tbio
MBOAT7
Lysophospholipid acyltransferase 7

Protein Summary
Description
Acyltransferase which contributes to the regulation of free arachidonic acid (AA) in the cell through the remodeling of phospholipids. Mediates the conversion of lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) into phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) (LPIAT activity). Prefers arachidonoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. Required for cortical lamination during brain development (By similarity). This gene encodes a member of the membrane-bound O-acyltransferases family of integral membrane proteins that have acyltransferase activity. The encoded protein is a lysophosphatidylinositol acyltransferase that has specificity for arachidonoyl-CoA as an acyl donor. This protein is involved in the reacylation of phospholipids as part of the phospholipid remodeling pathway known as the Land cycle. Alternative spli ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245615
  • ENSP00000245615
  • ENSG00000125505
  • ENST00000338624
  • ENSP00000344377
  • ENST00000391754
  • ENSP00000375634
  • ENST00000431666
  • ENSP00000410503
  • ENST00000610862
  • ENSP00000481119
  • ENSG00000276935
  • ENST00000611239
  • ENSP00000481947
  • ENSG00000277025
  • ENST00000611602
  • ENSP00000482369
  • ENSG00000278322
  • ENST00000612053
  • ENSP00000482884
  • ENSG00000278519
  • ENST00000612567
  • ENSP00000483526
  • ENSG00000277733
  • ENST00000613506
  • ENSP00000478965
  • ENSG00000274194
  • ENST00000613746
  • ENSP00000484933
  • ENSG00000275118
  • ENST00000614279
  • ENSP00000480894
  • ENST00000615282
  • ENSP00000483987
  • ENST00000615453
  • ENSP00000482625
  • ENST00000617012
  • ENSP00000484199
  • ENST00000617656
  • ENSP00000481864
  • ENST00000617772
  • ENSP00000480575
  • ENST00000618378
  • ENSP00000482252
  • ENST00000618826
  • ENSP00000483839
  • ENSG00000277923
  • ENST00000618899
  • ENSP00000480531
  • ENSG00000273592
  • ENST00000619670
  • ENSP00000479750
  • ENST00000619745
  • ENSP00000481544
  • ENST00000619842
  • ENSP00000481455
  • ENST00000619855
  • ENSP00000484954
  • ENST00000620311
  • ENSP00000478522
  • ENST00000620371
  • ENSP00000479760
  • ENST00000620636
  • ENSP00000482742
  • ENST00000621146
  • ENSP00000481758
  • ENST00000621455
  • ENSP00000477891
  • ENST00000621612
  • ENSP00000478088
  • ENST00000621875
  • ENSP00000478041

Symbol
  • BB1
  • LENG4
  • OACT7
  • BB1
  • LRC4
  • LENG4
  • LPIAT
  • LPLAT
  • MBOA7
  • MRT57
  • OACT7
  • hMBOA-7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.87
transcription factor perturbation
0.84
histone modification site profile
0.69
transcription factor
0.66
kinase perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.31   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.31   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0