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Tdark
TEPSIN
AP-4 complex accessory subunit Tepsin

Protein Summary
Description
Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300714
  • ENSP00000300714
  • ENSG00000167302

Symbol
  • C17orf56
  • ENTHD2
  • ENTHD2
  • C17orf56
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.28   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 12   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.28   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 12   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
AP4M1
Tbio
Novelty:  0.00142961
p_int:  0.999999995
p_ni:  5e-9
Score:  0.676
Data Source:  BioPlex,STRINGDB
AP4E1
Tdark
Novelty:  0.09773225
p_int:  0.999999994
p_ni:  5e-9
Score:  0.838
Data Source:  BioPlex,STRINGDB
AP4B1
Tbio
Novelty:  0.08255831
p_int:  0.999999986
p_ni:  1.1e-8
p_wrong:  3e-9
Score:  0.711
Data Source:  BioPlex,STRINGDB
MMACHC
Tbio
Novelty:  0.00896291
p_int:  0.99999949
p_ni:  1.5e-8
p_wrong:  4.95e-7
Data Source:  BioPlex
CCDC186
Tdark
Novelty:  0.44973807
p_int:  0.999999141
p_ni:  8.59e-7
Data Source:  BioPlex
AP4S1
Tdark
Novelty:  0.1142558
p_int:  0.99999233
p_ni:  4.1e-8
p_wrong:  0.000007628
Score:  0.713
Data Source:  BioPlex,STRINGDB
ISCA1
Tbio
Novelty:  0.01288069
p_int:  0.999983044
p_ni:  0.000016939
p_wrong:  1.7e-8
Data Source:  BioPlex
TRIM11
Tbio
Family:  Enzyme
Novelty:  0.02243955
p_int:  0.999902437
p_ni:  0.000097563
Data Source:  BioPlex
KIF1A
Tbio
Novelty:  0.00505209
p_int:  0.999777797
p_ni:  0.000222203
Data Source:  BioPlex
UBE3A
Tbio
Family:  Enzyme
Novelty:  0.00149368
p_int:  0.999150597
p_ni:  0.000849403
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
55.8
neutrophil percentage of leukocytes
1
1
1
44.2
lymphocyte percentage of leukocytes
1
1
1
30.2
vitamin D measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
55.8
neutrophil percentage of leukocytes
1
44.2
lymphocyte percentage of leukocytes
1
30.2
vitamin D measurement
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TEPSIN, adaptor related protein complex 4 accessory protein
VGNC:9424
746211
Macaque
TEPSIN, adaptor related protein complex 4 accessory protein
718666
Mouse
MGI:1926027
78777
Rat
RGD:1307410
360673
Dog
TEPSIN, adaptor related protein complex 4 accessory protein
VGNC:47251
608257
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TEPSIN, adaptor related protein complex 4 accessory protein
Macaque
TEPSIN, adaptor related protein complex 4 accessory protein
Mouse
Rat
Dog
TEPSIN, adaptor related protein complex 4 accessory protein
Publication Statistics
PubMed Score 3.28
PubMed score by year
PubTator Score 0.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title