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Tbio
GPR137
Integral membrane protein GPR137

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313074
  • ENSP00000321698
  • ENSG00000173264
  • ENST00000377702
  • ENSP00000366931
  • ENST00000411458
  • ENSP00000411827
  • ENST00000438980
  • ENSP00000415698
  • ENST00000539851
  • ENSP00000442792

Symbol
  • C11orf4
  • GPR137A
  • TM7SF1L1
  • C11orf4
  • GPR137A
  • TM7SF1L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.74
tissue sample
0.71
small molecule perturbation
0.68
cell type or tissue
0.62
transcription factor binding site profile
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.52   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.52   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (53)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
3
7
8
97.3
BMI-adjusted waist-hip ratio
6
7
11
97.3
urate measurement
1
5
5
95.7
triglyceride measurement
4
3
4
93.5
high density lipoprotein cholesterol measurement
5
3
5
92.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
8
97.3
BMI-adjusted waist-hip ratio
11
97.3
urate measurement
5
95.7
triglyceride measurement
4
93.5
high density lipoprotein cholesterol measurement
5
92.1
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 137
VGNC:6487
451292
Macaque
G protein-coupled receptor 137
717722
Mouse
MGI:2147529
107173
Rat
RGD:1586317
689984
Dog
G protein-coupled receptor 137
VGNC:41397
612124
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 137
Macaque
G protein-coupled receptor 137
Mouse
Rat
Dog
G protein-coupled receptor 137
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96N19-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (21)
1 – 10 of 21
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.995316444
p_ni:  0.000003589
p_wrong:  0.004679967
Score:  0.197
Data Source:  BioPlex,STRINGDB
LPAR1
Tchem
Family:  GPCR
Novelty:  0.00318056
p_int:  0.951493886
p_ni:  0.000076223
p_wrong:  0.048429891
Score:  0.203
Data Source:  BioPlex,STRINGDB
DPEP1
Tclin
Family:  Enzyme
Novelty:  0.00384946
p_int:  0.762169187
p_ni:  0.00006833
p_wrong:  0.237762483
Score:  0.177
Data Source:  BioPlex,STRINGDB
GPR108
Tbio
Novelty:  0.24228136
Score:  0.662
Data Source:  STRINGDB
GPR107
Tbio
Family:  GPCR
Novelty:  0.11706099
Score:  0.571
Data Source:  STRINGDB
GPR135
Tbio
Family:  GPCR
Novelty:  0.29123972
Score:  0.54
Data Source:  STRINGDB
OR6V1
Tdark
Family:  oGPCR
Novelty:  5.35714286
Score:  0.532
Data Source:  STRINGDB
OR51E2
Tchem
Family:  oGPCR
Novelty:  0.02435259
Score:  0.505
Data Source:  STRINGDB
GPRC5C
Tbio
Family:  GPCR
Novelty:  0.16942353
Score:  0.476
Data Source:  STRINGDB
TM7SF3
Tbio
Novelty:  0.12188681
Score:  0.464
Data Source:  STRINGDB
Publication Statistics
PubMed Score  14.52

PubMed score by year
PubTator Score  11.89

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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