Tbio COG8 Conserved oligomeric Golgi complex subunit 8

Protein Summary

Description

Required for normal Golgi function. This gene encodes a protein that is a component of the conserved oligomeric Golgi (COG) complex, a multiprotein complex that plays a structural role in the Golgi apparatus, and is involved in intracellular membrane trafficking and glycoprotein modification. Mutations in this gene cause congenital disorder of glycosylation, type IIh, a disease that is characterized by under-glycosylated serum proteins, and whose symptoms include severe psychomotor retardation, failure to thrive, seizures, and dairy and wheat product intolerance. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96MW5
• Q0VAK2
• Q8WVV6
• Q9H6F8
• COG complex subunit 8

Gene Name

• COG8

Ensembl ID

• ENST00000648169
• ENSP00000497669
• ENSG00000213380

Symbol

• DOR1
• CDG2H

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.9
tissue sample	0.73
transcription factor binding site profile	0.73
hub protein	0.67
cellular component	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.86   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 76   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.86   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (153)

Explore Interacting Targets

1 – 10 of 153

• See Interactions on String-DB

COG6

Tbio

Novelty:  0.02874093

p_int:  0.999999919

p_ni:  8e-8

p_wrong:  1e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

COG5

Tbio

Novelty:  0.04017657

p_int:  0.999999866

p_ni:  1.34e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

COG3

Tbio

Novelty:  0.02746711

p_int:  0.999999658

p_ni:  3.41e-7

p_wrong:  1e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

COG7

Tbio

Novelty:  0.07137701

p_int:  0.999999509

p_ni:  4.91e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

COG2

Tbio

Novelty:  0.03109287

p_int:  0.999999482

p_ni:  5.18e-7

p_wrong:  1e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

COMMD8

Tdark

Novelty:  0.33240242

p_int:  0.999357305

p_ni:  0.000642694

Score:  0.609

Data Source:  BioPlex,STRINGDB

VSIG2

Tdark

Novelty:  0.32398032

p_int:  0.999292278

p_ni:  0.000707721

p_wrong:  1e-9

Score:  0.764

Data Source:  BioPlex,STRINGDB

BSG

Tbio

Novelty:  0.0010285

p_int:  0.995554791

p_ni:  0.004445208

Score:  0.192

Data Source:  BioPlex,STRINGDB

SIGLECL1

Tdark

p_int:  0.989154057

p_ni:  0.010741591

p_wrong:  0.000104351

Data Source:  BioPlex

OPRM1

Tclin

Family:  GPCR

Novelty:  0.0003701

p_int:  0.978749232

p_ni:  0.019648729

p_wrong:  0.00160204

Score:  0.695

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (11)

Reactome (11)

Asparagine N-linked glycosylation (R-HSA-446203)

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5

1 – 5 of 11

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Asparagine N-linked glycosylation	286 targets	R-HSA-446203
Reactome	COPI-mediated anterograde transport	83 targets	R-HSA-6807878
Reactome	ER to Golgi Anterograde Transport	136 targets	R-HSA-199977
Reactome	Intra-Golgi and retrograde Golgi-to-ER traffic	187 targets	R-HSA-6811442
Reactome	Intra-Golgi traffic	45 targets	R-HSA-6811438

Name	Explore in Pharos	Explore in Source
Asparagine N-linked glycosylation	286 targets	R-HSA-446203
COPI-mediated anterograde transport	83 targets	R-HSA-6807878
ER to Golgi Anterograde Transport	136 targets	R-HSA-199977
Intra-Golgi and retrograde Golgi-to-ER traffic	187 targets	R-HSA-6811442
Intra-Golgi traffic	45 targets	R-HSA-6811438

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (8)

Components (5)

Processes (3)

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Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
Golgi apparatus	Inferred from Direct Assay (IDA)	HPA
Golgi transport complex	Inferred from Direct Assay (IDA)	UniProtKB
membrane	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
Golgi membrane	Traceable Author Statement (TAS)	Reactome
trans-Golgi network membrane	Traceable Author Statement (TAS)	Reactome

Disease Associations ()

No disease associations found

GWAS Traits (8)

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5

1 – 5 of 8

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	4	2	4		80.6
daytime rest measurement	EFO_0007828	1	1	1		55.2
telomere length	EFO_0004505	1	1	1		38.8
apolipoprotein A 1 measurement	EFO_0004614	1	1	1		35
total cholesterol measurement	EFO_0004574	1	1	1		33.1

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 8

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	4		80.6
daytime rest measurement	EFO_0007828	1		55.2
telomere length	EFO_0004505	1		38.8
apolipoprotein A 1 measurement	EFO_0004614	1		35
total cholesterol measurement	EFO_0004574	1		33.1

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Congenital disorder of glycosylation
Golgi apparatus
Membrane
Polymorphism
Protein transport
Reference proteome
Transport

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
biological sex
daytime rest measurement
heel bone mineral density
high density lipoprotein cholesterol measurement
telomere length
total cholesterol measurement
triglyceride measurement

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	component of oligomeric golgi complex 8		454199
Mouse	component of oligomeric golgi complex 8	MGI:2142885	97484
Rat	component of oligomeric golgi complex 8	RGD:1307074	291990
Dog	component of oligomeric golgi complex 8		489737
Horse	component of oligomeric golgi complex 8		100067058

Species	Name	OMA	EggNOG	Inparanoid
Chimp	component of oligomeric golgi complex 8
Mouse	component of oligomeric golgi complex 8
Rat	component of oligomeric golgi complex 8
Dog	component of oligomeric golgi complex 8
Horse	component of oligomeric golgi complex 8

Publication Statistics

PubMed Score 37.86

PubMed score by year

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PubTator Score 7.99

PubTator score by year

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Related Publications

Text Mined References (22)

GeneRif Annotations (5)

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10

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PMID	Year	Title