Tbio COG8 Conserved oligomeric Golgi complex subunit 8

Protein Summary

Description

Required for normal Golgi function. This gene encodes a protein that is a component of the conserved oligomeric Golgi (COG) complex, a multiprotein complex that plays a structural role in the Golgi apparatus, and is involved in intracellular membrane trafficking and glycoprotein modification. Mutations in this gene cause congenital disorder of glycosylation, type IIh, a disease that is characterized by under-glycosylated serum proteins, and whose symptoms include severe psychomotor retardation, failure to thrive, seizures, and dairy and wheat product intolerance. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96MW5
• Q0VAK2
• Q8WVV6
• Q9H6F8
• COG complex subunit 8

Gene Name

• COG8

Ensembl ID

• ENST00000648169
• ENSP00000497669
• ENSG00000213380

Symbol

• DOR1
• CDG2H

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.9
tissue sample	0.73
transcription factor binding site profile	0.73
hub protein	0.67
cellular component	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.55   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 76   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.55   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0