You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CEP63
Centrosomal protein of 63 kDa

Protein Summary
Description
Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned (PubMed:21983783, PubMed:26297806). Also recruits CDK1 to centrosomes (PubMed:21406398). Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (PubMed:21406398). This gene encodes a protein with six coiled-coil domains. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. Several alternatively spliced transcript variants have been found, but their biological vali ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332047
  • ENSP00000328382
  • ENSG00000182923
  • ENST00000337090
  • ENSP00000336524
  • ENST00000354446
  • ENSP00000346432
  • ENST00000383229
  • ENSP00000372716
  • ENST00000513612
  • ENSP00000426129
  • ENST00000606977
  • ENSP00000475903
  • ENST00000620544
  • ENSP00000482219

Symbol
  • SCKL6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
virus perturbation
0.79
cell type or tissue
0.76
transcription factor
0.7
transcription factor binding site profile
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.77   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.77   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (166)
TXLNB
Tbio
Novelty:  0.12751933
p_int:  0.999971514
p_ni:  0.000028371
p_wrong:  1.15e-7
Score:  0.39
Data Source:  BioPlex,STRINGDB
BFSP1
Tbio
Novelty:  0.01519136
p_int:  0.999937192
p_ni:  0.000062798
p_wrong:  1e-8
Data Source:  BioPlex
EPS15L1
Tbio
Novelty:  0.06929299
p_int:  0.923993023
p_ni:  0.000799853
p_wrong:  0.075207124
Data Source:  BioPlex
CEP152
Tbio
Novelty:  0.02129779
Score:  0.996
Data Source:  STRINGDB
CEP135
Tbio
Novelty:  0.03507768
Score:  0.989
Data Source:  STRINGDB
CDK5RAP2
Tbio
Novelty:  0.00956263
Score:  0.983
Data Source:  STRINGDB
PLK4
Tchem
Family:  Kinase
Novelty:  0.00265851
Score:  0.982
Data Source:  STRINGDB
CENPJ
Tbio
Novelty:  0.01337231
Score:  0.98
Data Source:  STRINGDB
CEP57
Tbio
Novelty:  0.05529464
Score:  0.971
Data Source:  STRINGDB
CEP192
Tbio
Novelty:  0.05738998
Score:  0.963
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (156)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
6
6
12
75.1
waist circumference
1
2
2
62
smoking behavior
1
1
2
55.2
body height
1
1
1
27.2
BMI-adjusted hip circumference
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
12
75.1
waist circumference
2
62
smoking behavior
2
55.2
body height
1
27.2
BMI-adjusted hip circumference
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 63
VGNC:11371
460713
Macaque
centrosomal protein 63
717266
Mouse
MGI:2158560
28135
Rat
RGD:1561183
300963
Dog
centrosomal protein 63
VGNC:39133
477075
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 63
Macaque
centrosomal protein 63
Mouse
Rat
Dog
centrosomal protein 63
Publication Statistics
PubMed Score 14.77
PubMed score by year
PubTator Score 7.78
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title