KCTD7
BTB/POZ domain-containing protein KCTD7
Protein Summary
May be involved in the control of excitability of cortical neurons. This gene encodes a member of the potassium channel tetramerization domain-containing protein family. Family members are identified on a structural basis and contain an amino-terminal domain similar to the T1 domain present in the voltage-gated potassium channel. Mutations in this gene have been associated with progressive myoclonic epilepsy-3. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011]
- ENST00000443322
- ENSP00000411624
- ENSG00000243335
- ENST00000639828
- ENSP00000492240
- EPM3
- CLN14
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.83 | ||
microRNA | 0.7 | ||
transcription factor binding site profile | 0.7 | ||
transcription factor perturbation | 0.61 | ||
small molecule perturbation | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.91 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 115 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.91 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 115 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0