You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
ZNF488
Zinc finger protein 488

Protein Summary
Description
Transcriptional repressor. Plays a role in oligodendrocyte differentiation, together with OLIG2. Mediates Notch signaling-activated formation of oligodendrocyte precursors. Promotes differentiation of adult neural stem progenitor cells (NSPCs) into mature oligodendrocytes and contributes to remyelination following nerve injury.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000585316
  • ENSP00000462269
  • ENSG00000265763
  • ENST00000591025
  • ENSP00000468133
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.75
biological process
0.69
cell type or tissue
0.54
microRNA
0.54
cell line
0.53


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.94   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.94   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
1
2
75.2
hemoglobin measurement
2
1
2
71.6
red blood cell density measurement
1
1
1
65.4
corneal topography
2
1
2
59
systolic blood pressure
1
1
1
52.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
75.2
hemoglobin measurement
2
71.6
red blood cell density measurement
1
65.4
corneal topography
2
59
systolic blood pressure
1
52.4
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2686052
382867
Rat
RGD:1309835
290571
Dog
zinc finger protein 488
VGNC:48739
489083
Horse
zinc finger protein 488
VGNC:25329
100063727
Platypus
zinc finger protein 488
100076427
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
zinc finger protein 488
Horse
zinc finger protein 488
Platypus
zinc finger protein 488
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96MN9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (38)
1 – 10 of 38
USO1
Tbio
Novelty:  0.02066669
p_int:  0.998643386
p_ni:  0.001356614
Score:  0.188
Data Source:  BioPlex,STRINGDB
CTH
Tchem
Family:  Enzyme
Novelty:  0.0017155
p_int:  0.987812068
p_ni:  0.012187902
p_wrong:  3e-8
Score:  0.22
Data Source:  BioPlex,STRINGDB
GOPC
Tbio
Novelty:  0.01110168
p_int:  0.943934882
p_ni:  0.056065118
Score:  0.15
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.895391559
p_ni:  0.104608441
Data Source:  BioPlex
CAMK2G
Tchem
Family:  Kinase
Novelty:  0.04642387
p_int:  0.824752974
p_ni:  0.175247026
Score:  0.313
Data Source:  BioPlex,STRINGDB
PRDM13
Tbio
Family:  TF; Epigenetic
Novelty:  0.08359319
Score:  0.624
Data Source:  STRINGDB
PRDM6
Tbio
Family:  TF; Epigenetic
Novelty:  0.04172889
Score:  0.59
Data Source:  STRINGDB
MPPE1
Tbio
Family:  Enzyme
Novelty:  0.16027847
Score:  0.577
Data Source:  STRINGDB
OLIG1
Tbio
Family:  TF
Novelty:  0.01006324
Score:  0.57
Data Source:  STRINGDB
PRDM11
Tbio
Family:  Epigenetic
Novelty:  0.30063286
Score:  0.557
Data Source:  STRINGDB
Publication Statistics
PubMed Score  2.94

PubMed score by year
PubTator Score  1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer