Tbio HSPA12B Heat shock 70 kDa protein 12B

Protein Summary

Description

The protein encoded by this gene contains an atypical heat shock protein 70 (Hsp70) ATPase domain and is therefore a distant member of the mammalian Hsp70 family. This gene may be involved in susceptibility to atherosclerosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

Uniprot Accession IDs

• Q96MM6
• D3DVX7
• Q2TAK3
• Q9BR52

Gene Name

• HSPA12B

Ensembl ID

• ENST00000254963
• ENSP00000254963
• ENSG00000132622

Symbol

• C20orf60
• C20orf60

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.76
drug perturbation	0.71
gene perturbation	0.65
tissue sample	0.63
cellular component	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.73   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 113   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.73   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0