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Tbio
HSPA12B
Heat shock 70 kDa protein 12B

Protein Summary
Description
The protein encoded by this gene contains an atypical heat shock protein 70 (Hsp70) ATPase domain and is therefore a distant member of the mammalian Hsp70 family. This gene may be involved in susceptibility to atherosclerosis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254963
  • ENSP00000254963
  • ENSG00000132622

Symbol
  • C20orf60
  • C20orf60
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.76
drug perturbation
0.71
gene perturbation
0.65
tissue sample
0.63
cellular component
0.53


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.61   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.61   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
6
6
96.9
reticulocyte count
5
5
7
92.4
mean corpuscular volume
1
2
2
91.7
reticulocyte measurement
2
2
3
88.4
mean reticulocyte volume
1
2
2
77.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
6
96.9
reticulocyte count
7
92.4
mean corpuscular volume
2
91.7
reticulocyte measurement
3
88.4
mean reticulocyte volume
2
77.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heat shock protein family A (Hsp70) member 12B
VGNC:9870
458062
Macaque
heat shock protein family A (Hsp70) member 12B
718521
Mouse
MGI:1919880
72630
Dog
heat shock protein family A (Hsp70) member 12B
VGNC:53543
485793
Horse
heat shock protein family A (Hsp70) member 12B
VGNC:51553
100066324
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heat shock protein family A (Hsp70) member 12B
Macaque
heat shock protein family A (Hsp70) member 12B
Mouse
Dog
heat shock protein family A (Hsp70) member 12B
Horse
heat shock protein family A (Hsp70) member 12B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96MM6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Cellular response to heat stress (R-HSA-3371556)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Regulation of HSF1-mediated heat shock response
Name
Explore in Pharos
Explore in Source
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
Regulation of HSF1-mediated heat shock response
Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (107)
1 – 10 of 107
EPB41L3
Tbio
Novelty:  0.00915217
p_int:  0.999754582
p_ni:  0.000155264
p_wrong:  0.000090154
Data Source:  BioPlex
PODXL
Tbio
Novelty:  0.00306913
p_int:  0.970584894
p_ni:  0.000001085
p_wrong:  0.029414021
Score:  0.393
Data Source:  BioPlex,STRINGDB
HSPA4
Tbio
Novelty:  0.00009122
Score:  0.966
Data Source:  STRINGDB
HSPA1A
Tchem
Novelty:  0.00069195
Score:  0.962
Data Source:  STRINGDB
HSPA9
Tchem
Novelty:  0.00235171
Score:  0.954
Data Source:  STRINGDB
HSPH1
Tbio
Novelty:  0.01617555
Score:  0.952
Data Source:  STRINGDB
DNAJC2
Tbio
Family:  TF
Novelty:  0.01515066
Score:  0.952
Data Source:  STRINGDB
HSPA14
Tbio
Novelty:  0.01714625
Score:  0.949
Data Source:  STRINGDB
HSPA4L
Tbio
Novelty:  0.05591399
Score:  0.944
Data Source:  STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
Score:  0.943
Data Source:  STRINGDB
Publication Statistics
PubMed Score  24.61

PubMed score by year
PubTator Score  8.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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