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Tbio
NSMCE3
Non-structural maintenance of chromosomes element 3 homolog

Protein Classes
Protein Summary
Description
Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:20864041, PubMed:27427983). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:20864041). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (By similarity). The protein encoded by this gene is part of the SMC5-6 chromatin reorganizing complex and is a member of the MAGE superf ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332303
  • ENSP00000330694
  • ENSG00000185115
  • ENST00000631973
  • ENSP00000487893
  • ENSG00000282130

Symbol
  • HCA4
  • MAGEG1
  • NDNL2
  • HCA4
  • LICS
  • NSE3
  • NDNL2
  • MAGEG1
  • MAGEL3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.31   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 40   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.31   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 40   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96MG7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
SUMO E3 ligases SUMOylate target proteins
Reactome
SUMOylation
Reactome
SUMOylation of DNA damage response and repair proteins
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
SUMO E3 ligases SUMOylate target proteins
SUMOylation
SUMOylation of DNA damage response and repair proteins
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (62)
1 – 10 of 62
NSMCE1
Tdark
Novelty: 0.75370409
p_int: 0.999999944
p_ni: 5.5e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
NSMCE4A
Tdark
Novelty: 0.45550673
p_int: 0.999999904
p_ni: 9.6e-8
Score: 0.996
Data Source: BioPlex,STRINGDB
EID3
Tdark
Novelty: 0.37412011
p_int: 0.999998267
p_ni: 0.000001733
Score: 0.994
Data Source: BioPlex,STRINGDB
ZNF597
Tbio
Family: TF
Novelty: 0.04420398
p_int: 0.999998228
p_ni: 0.000001772
Score: 0.83
Data Source: BioPlex,STRINGDB
STN1
Tbio
Novelty: 0.01309587
p_int: 0.993034172
p_ni: 0.006965828
Score: 0.546
Data Source: BioPlex,STRINGDB
PJA1
Tbio
Family: Enzyme
Novelty: 0.06148437
p_int: 0.985249447
p_ni: 0.014750453
p_wrong: 1e-7
Score: 0.782
Data Source: BioPlex,STRINGDB
NSMCE2
Tbio
Family: Enzyme
Novelty: 0.02320995
Score: 0.999
Data Source: STRINGDB
SMC6
Tbio
Novelty: 0.02450073
Score: 0.999
Data Source: STRINGDB
SMC5
Tbio
Novelty: 0.008623
Score: 0.998
Data Source: STRINGDB
SMC3
Tbio
Novelty: 0.00474377
Score: 0.951
Data Source: STRINGDB
Publication Statistics
PubMed Score  23.31

PubMed score by year
PubTator Score  10.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer