Tbio NSMCE3 Non-structural maintenance of chromosomes element 3 homolog

Protein Summary

Description

Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:20864041, PubMed:27427983). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:20864041). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (By similarity). The protein encoded by this gene is part of the SMC5-6 chromatin reorganizing complex and is a member of the MAGE superfamily. This is an intronless gene. [provided by RefSeq, May 2011]

Uniprot Accession IDs

• Q96MG7
• Q8IW16
• Q8TEI6
• Q9H214
• Non-SMC element 3 homolog

Gene Name

• NSMCE3

Ensembl ID

• ENST00000332303
• ENSP00000330694
• ENSG00000185115
• ENST00000631973
• ENSP00000487893
• ENSG00000282130

Symbol

• HCA4
• MAGEG1
• NDNL2
• HCA4
• LICS
• NSE3
• NDNL2
• MAGEG1
• MAGEL3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

PANTHER Classes

Protein / Cell Adhesion Molecule / Non-structural Maintenance Of Chromosomes Element 3 Homolog

DTO Classes

Protein / Cell Adhesion / Non-structural Maintenance Of Chromosomes Element 3 Homolog

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.58   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 40   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.58   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 40   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0